Flt1 Fms related receptor tyrosine kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Flt1provided by RGD
Official Full Name: Fms related receptor tyrosine kinase 1provided by RGD
Primary source: RGD:2621
See related: EnsemblRapid:ENSRNOG00000000940 AllianceGenome:RGD:2621
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: FLT-1; VEGFR-1
Summary: Enables ATP binding activity; growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including liver regeneration; negative regulation of vascular endothelial growth factor production; and positive regulation of cell population proliferation. Located in extracellular space and plasma membrane. Used to study corneal neovascularization. Biomarker of breast cancer; diabetic retinopathy; liver cirrhosis; myocardial infarction; and vascular dementia. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 293.4), Heart (RPKM 182.9) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (12333050..12504750)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (7296899..7468626)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (9033993..9205886)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pigment Epithelium-Derived Factor Binding to VEGFR-1 (Flt-1) Increases the Survival of Retinal Neurons.
Title: Pigment Epithelium-Derived Factor Binding to VEGFR-1 (Flt-1) Increases the Survival of Retinal Neurons.
Wnt5a-Flt1 activation contributes to preterm altered cerebral angiogenesis after prenatal inflammation.
Title: Wnt5a-Flt1 activation contributes to preterm altered cerebral angiogenesis after prenatal inflammation.
Effects of Cerebral Ischemia on Levels of Vascular Endothelial Growth Factor (VEGF) and Its Soluble Receptors: A Possible Link to Angiogenesis in Arteriovenous Malformations.
Title: Effects of Cerebral Ischemia on Levels of Vascular Endothelial Growth Factor (VEGF) and Its Soluble Receptors: A Possible Link to Angiogenesis in Arteriovenous Malformations.
Co- localization of Flt1 and tryptase of mast cells in skin wound of rats with type I diabetes: Initial studies.
Title: Co- localization of Flt1 and tryptase of mast cells in skin wound of rats with type I diabetes: Initial studies.
Acute kidney injury during pregnancy leads to increased sFlt-1 and sEng and decreased renal T regulatory cells in pregnant rats with HELLP syndrome.
Title: Acute kidney injury during pregnancy leads to increased sFlt-1 and sEng and decreased renal T regulatory cells in pregnant rats with HELLP syndrome.
Differential regulation of sFlt-1 splicing by U2AF65 and JMJD6 in placental-derived and endothelial cells.
Title: Differential regulation of sFlt-1 splicing by U2AF65 and JMJD6 in placental-derived and endothelial cells.
Our studies suggest that, subsequent to VEGF-A binding and internalization, the unoccupied VEGFR1 may recycle to the cell surface allowing its reutilization, whereas the majority of the internalized VEGFR2 is targeted for degradation.
Title: Receptor-Mediated Endocytosis of VEGF-A in Rat Liver Sinusoidal Endothelial Cells.
effects of lipopolysaccharide (LPS)-induced intrauterine inflammation on placenta angiogenesis and Wnt5a-Flt1 expression.
Title: Intrauterine Inflammation Damages Placental Angiogenesis via Wnt5a-Flt1 Activation.
Melatonin affects placental expression of TNFalpha, IL-6, VEGF and sFlt-1 in a rat model of preeclampsia.
Title: Effects of Melatonin on Blood Pressure, Oxidative Stress and Placental Expressions of TNFα, IL-6, VEGF and sFlt-1 in RUPP Rat Model of Preeclampsia.
Maternal and fetal detrimental changes along with increases in circulating sFlt-1 and VEGF in hypertensive pregnancy may be associated with increases in cardiac and circulating MPO activities, confirming the causative role of inflammatory response in preeclampsia.
Title: Cardiac myeloperoxidase activity is elevated in hypertensive pregnant rats.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Flt1 (e-PCR), detects polymorphism
- UniSTS:143118

BF390975 (e-PCR)
- UniSTS:249623

AW534418 (e-PCR)
- UniSTS:246579

Flt1 (e-PCR), detects polymorphism
- UniSTS:280402

RH94413 (e-PCR)
- UniSTS:119661

RH142805 (e-PCR)
- UniSTS:232052

AW531954 (e-PCR)
- UniSTS:245137

D12Got4 (e-PCR)
- UniSTS:112609

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables vascular endothelial growth factor receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables vascular endothelial growth factor receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in embryonic morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in hyaloid vascular plexus regression	ISO Inferred from Sequence Orthology more info
involved_in hyaloid vascular plexus regression	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in monocyte chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular endothelial growth factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of vascular permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of smooth muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in response to activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hypoxia	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor receptor-1 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vascular endothelial growth factor receptor 1

Names: FMS-like tyrosine kinase 1; Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1-like; vascular endothelial growth factor/vascular permeability factor receptor

NP_001296310.1

EC 2.7.10.1

NP_062179.2

EC 2.7.10.1

XP_008767220.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001309381.1 → NP_001296310.1 vascular endothelial growth factor receptor 1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001296310.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

JAXUCZ010000012

UniProtKB/TrEMBL

A6K198, Q9JJ08

Conserved Domains (4) summary

cd00096
Location:451 → 549

Ig; Immunoglobulin domain

smart00408
Location:569 → 640

IGc2; Immunoglobulin C-2 Type

smart00410
Location:237 → 328

IG_like; Immunoglobulin like

cl11960
Location:353 → 424

Ig; Immunoglobulin domain
NM_019306.2 → NP_062179.2 vascular endothelial growth factor receptor 1 isoform 1 precursor

See identical proteins and their annotated locations for NP_062179.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P53767

UniProtKB/TrEMBL

A6K197

Related

ENSRNOP00000001248.3, ENSRNOT00000001248.5

Conserved Domains (8) summary

cd00096
Location:451 → 549

Ig; Immunoglobulin domain

smart00408
Location:676 → 738

IGc2; Immunoglobulin C-2 Type

smart00409
Location:568 → 640

IG; Immunoglobulin

smart00410
Location:237 → 328

IG_like; Immunoglobulin like

pfam07679
Location:661 → 748

I-set; Immunoglobulin I-set domain

pfam07714
Location:827 → 1154

Pkinase_Tyr; Protein tyrosine kinase

cl11960
Location:353 → 424

Ig; Immunoglobulin domain

cl21453
Location:819 → 1157

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086030.1 Reference GRCr8

Range

12333050..12504750

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008768998.4 → XP_008767220.1 vascular endothelial growth factor receptor 1 isoform X1

UniProtKB/TrEMBL

Q9JJ08

Conserved Domains (5) summary

cd00096
Location:451 → 549

Ig; Immunoglobulin domain

smart00408
Location:569 → 640

IGc2; Immunoglobulin C-2 Type

smart00410
Location:237 → 328

IG_like; Immunoglobulin like

pfam13895
Location:666 → 736

Ig_2; Immunoglobulin domain

cl11960
Location:353 → 424

Ig; Immunoglobulin domain