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    Zfp287 zinc finger protein 287 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303212, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Zfp287provided by RGD
    Official Full Name
    zinc finger protein 287provided by RGD
    Primary source
    RGD:1308617
    See related
    EnsemblRapid:ENSRNOG00000003215 AllianceGenome:RGD:1308617
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf287
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of cytokine production. Predicted to be active in nucleus. Orthologous to human ZNF287 (zinc finger protein 287). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 37.6), Lung (RPKM 35.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp287 in Genome Data Viewer
    Location:
    10q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (47896517..47914860, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (47395650..47415610, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (49131764..49150930, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 75A Neighboring gene uncharacterized LOC120095115 Neighboring gene membrane magnesium transporter 2 Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA tryptophan (anticodon CCA) 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of SKAT-2, a novel Th2-specific zinc finger gene. Blanchard AD, et al. Eur J Immunol, 2000 Nov. PMID 11093124
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 287

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107008.2 → NP_001100478.1  zinc finger protein 287

      See identical proteins and their annotated locations for NP_001100478.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HFB9, D4A516
      Conserved Domains (7) summary
      smart00349
      Location:168 → 225
      KRAB; krueppel associated box
      COG5048
      Location:420 → 752
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424 → 444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:590 → 612
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:168 → 207
      KRAB; KRAB box
      pfam02023
      Location:46 → 133
      SCAN; SCAN domain
      pfam13465
      Location:604 → 629
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      47896517..47914860 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246692.5 → XP_006246754.1  zinc finger protein 287 isoform X1

      See identical proteins and their annotated locations for XP_006246754.1

      UniProtKB/TrEMBL
      A6HFB9, D4A516
      Related
      ENSRNOP00000004291.4, ENSRNOT00000004291.7
      Conserved Domains (7) summary
      smart00349
      Location:168 → 225
      KRAB; krueppel associated box
      COG5048
      Location:420 → 752
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:424 → 444
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:590 → 612
      zf-C2H2; Zinc finger, C2H2 type
      pfam01352
      Location:168 → 207
      KRAB; KRAB box
      pfam02023
      Location:46 → 133
      SCAN; SCAN domain
      pfam13465
      Location:604 → 629
      zf-H2C2_2; Zinc-finger double domain

    2. XM_017597279.3 → XP_017452768.1  zinc finger protein 287 isoform X2

    3. XM_039085973.2 → XP_038941901.1  zinc finger protein 287 isoform X3

      Conserved Domains (2) summary
      smart00349
      Location:168 → 225
      KRAB; krueppel associated box
      cl02605
      Location:46 → 144
      SCAN; SCAN oligomerization domain

    RNA

    1. XR_005489814.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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