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    Cpsf7 cleavage and polyadenylation specific factor 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365407, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Cpsf7provided by RGD
    Official Full Name
    cleavage and polyadenylation specific factor 7provided by RGD
    Primary source
    RGD:1305441
    See related
    EnsemblRapid:ENSRNOG00000020668 AllianceGenome:RGD:1305441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305441
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA alternative polyadenylation; pre-mRNA cleavage required for polyadenylation; and protein-containing complex assembly. Predicted to be located in cytoplasm and nucleus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF7 (cleavage and polyadenylation specific factor 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 275.0), Spleen (RPKM 223.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cpsf7 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (216592745..216616860)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (207167690..207191938)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (226572399..226596185)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483971 Neighboring gene stabilizer of axonemal microtubules 4 Neighboring gene succinate dehydrogenase complex assembly factor 2 Neighboring gene 5S ribosomal RNA Neighboring gene transmembrane protein 216

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cleavage factor Im is a key regulator of 3' UTR length. Gruber AR, et al. RNA Biol, 2012 Dec. PMID 23187700
    2. Evidence that cleavage factor Im is a heterotetrameric protein complex controlling alternative polyadenylation. Kim S, et al. Genes Cells, 2010 Sep 1. PMID 20695905
    3. Molecular Mechanisms for CFIm-Mediated Regulation of mRNA Alternative Polyadenylation. Zhu Y, et al. Mol Cell, 2018 Jan 4. PMID 29276085, Free PMC Article
    4. Mammalian pre-mRNA 3' end processing factor CF I m 68 functions in mRNA export. Ruepp MD, et al. Mol Biol Cell, 2009 Dec. PMID 19864460, Free PMC Article
    5. Pre-mRNA 3'-end processing complex assembly and function. Chan S, et al. Wiley Interdiscip Rev RNA, 2011 May-Jun. PMID 21957020, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA alternative polyadenylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA alternative polyadenylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA alternative polyadenylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA alternative polyadenylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein heterotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cleavage factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mRNA cleavage factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cleavage and polyadenylation specificity factor subunit 7
    Names
    cleavage and polyadenylation specific factor 7, 59kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014245.3 → NP_001014267.1  cleavage and polyadenylation specificity factor subunit 7 isoform 2

      See identical proteins and their annotated locations for NP_001014267.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5XI29
      Related
      ENSRNOP00000108140.1, ENSRNOT00000166988.1
      Conserved Domains (1) summary
      cd12644
      Location:81 → 170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

    2. NM_001399757.1 → NP_001386686.1  cleavage and polyadenylation specificity factor subunit 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8L2QG69
      Related
      ENSRNOP00000028074.6, ENSRNOT00000028074.7
      Conserved Domains (2) summary
      COG0724
      Location:20 → 231
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12644
      Location:81 → 170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      216592745..216616860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085585.2 → XP_038941513.1  cleavage and polyadenylation specificity factor subunit 7 isoform X1

      UniProtKB/TrEMBL
      A0A8L2QG69
      Conserved Domains (2) summary
      COG0724
      Location:20 → 231
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12644
      Location:81 → 170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

    2. XM_039085601.2 → XP_038941529.1  cleavage and polyadenylation specificity factor subunit 7 isoform X2

      Conserved Domains (2) summary
      COG0724
      Location:20 → 231
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12644
      Location:81 → 170
      RRM_CFIm59; RNA recognition motif (RRM) found in pre-mRNA cleavage factor Im 59 kDa subunit (CFIm59 or CPSF7) and similar proteins

    3. XM_039085607.2 → XP_038941535.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

      Conserved Domains (1) summary
      cl17169
      Location:23 → 101
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_063269902.1 → XP_063125972.1  cleavage and polyadenylation specificity factor subunit 7 isoform X3

    5. XM_063269906.1 → XP_063125976.1  cleavage and polyadenylation specificity factor subunit 7 isoform X4

    6. XM_063269909.1 → XP_063125979.1  cleavage and polyadenylation specificity factor subunit 7 isoform X5

    RNA

    1. XR_010055264.1 RNA Sequence

    2. XR_010055261.1 RNA Sequence

    3. XR_010055267.1 RNA Sequence

    4. XR_010055266.1 RNA Sequence

    5. XR_010055265.1 RNA Sequence

    6. XR_010055262.1 RNA Sequence

    7. XR_010055263.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI29.1 GenPept UniProtKB/Swiss-Prot:Q5XI29

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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