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    Atp6v1c1 ATPase H+ transporting V1 subunit C1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299971, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atp6v1c1provided by RGD
    Official Full Name
    ATPase H+ transporting V1 subunit C1provided by RGD
    Primary source
    RGD:1311082
    See related
    EnsemblRapid:ENSRNOG00000004846 AllianceGenome:RGD:1311082
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in synaptic vesicle lumen acidification. Located in apical part of cell. Is extrinsic component of synaptic vesicle membrane. Orthologous to human ATP6V1C1 (ATPase H+ transporting V1 subunit C1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 614.4), Kidney (RPKM 396.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp6v1c1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (71719326..71757191)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (69834464..69872278)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (77678853..77716658)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093641 Neighboring gene uncharacterized LOC102550582 Neighboring gene uncharacterized LOC134479714 Neighboring gene BAALC binder of MAP3K1 and KLF4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of ATP6V1C1 during oral carcinogenesis. Oliveira Alves MG, et al. Biotech Histochem, 2016. PMID 26984774
    2. A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer patients. Cheng L, et al. Genomics, 2013 Oct. PMID 23722107
    3. Functional expression of V-ATPases in the plasma membrane of glial cells. Philippe JM, et al. Glia, 2002 Mar 15. PMID 11870875
    4. Silencing of atp6v1c1 prevents breast cancer growth and bone metastasis. Feng S, et al. Int J Biol Sci, 2013. PMID 24155661, Free PMC Article
    5. Distinct expression patterns of different subunit isoforms of the V-ATPase in the rat epididymis. Pietrement C, et al. Biol Reprod, 2006 Jan. PMID 16192400

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109315

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proton-transporting ATPase activity, rotational mechanism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic vesicle lumen acidification ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in clathrin-coated vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of synaptic vesicle membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in extrinsic component of synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of proton-transporting V-type ATPase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proton-transporting V-type ATPase, V1 domain IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting V-type ATPase, V1 domain ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    V-type proton ATPase subunit C 1
    Names
    ATPase, H+ transporting, V1 subunit C
    ATPase, H+ transporting, lysosomal V1 subunit C1
    V-ATPase subunit C 1
    vacuolar proton pump subunit C 1
    NP_001011992.1
    XP_006241664.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011992.1 → NP_001011992.1  V-type proton ATPase subunit C 1

      See identical proteins and their annotated locations for NP_001011992.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089961
      UniProtKB/Swiss-Prot
      Q5FVI6
      UniProtKB/TrEMBL
      A0A8I5Y7J1
      Related
      ENSRNOP00000006917.4, ENSRNOT00000006917.7
      Conserved Domains (2) summary
      cd14785
      Location:56 → 76
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 370
      V-ATPase_C; V-ATPase subunit C

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      71719326..71757191
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241602.5 → XP_006241664.1  V-type proton ATPase subunit C 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y7J1, A0A8I6GCD8
      Related
      ENSRNOP00000085031.1, ENSRNOT00000104331.2
      Conserved Domains (2) summary
      cd14785
      Location:56 → 76
      V-ATPase_C; 3-helical coiled coil [structural motif]
      pfam03223
      Location:5 → 337
      V-ATPase_C; V-ATPase subunit C

    RNA

    1. XR_010052959.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FVI6.1 GenPept UniProtKB/Swiss-Prot:Q5FVI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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