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    Lrp11 LDL receptor related protein 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292462, updated on 17-Aug-2024

    Summary

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    Symbol
    Lrp11provided by RGD
    Full Name
    LDL receptor related protein 11provided by RGD
    Primary source
    RGD:1308602
    See related
    EnsemblRapid:ENSRNOG00000014303 AllianceGenome:RGD:1308602
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphoprotein binding activity. Predicted to act upstream of or within several processes, including response to cold; response to immobilization stress; and response to water deprivation. Predicted to be integral component of membrane. Orthologous to human LRP11 (LDL receptor related protein 11). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 240.7), Kidney (RPKM 133.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lrp11 in Genome Data Viewer
    Location:
    1p13
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (3868665..3928513)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (2048307..2108115)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (1702696..1731210)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene feminization of XX and XO animals 1B, pseudogene 1 Neighboring gene retinoic acid early transcript 1L like 2 Neighboring gene ribosomal protein L23a, pseudogene 6 Neighboring gene uncharacterized LOC120098770 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Neighboring gene nucleoporin 43 Neighboring gene large tumor suppressor kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genetic regulatory network analysis reveals that low density lipoprotein receptor-related protein 11 is involved in stress responses in mice. Xu J, et al. Psychiatry Res, 2014 Dec 30. PMID 25262641
    2. Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Xiao K, et al. Proc Natl Acad Sci U S A, 2007 Jul 17. PMID 17620599, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphoprotein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in multicellular organismal response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to cold ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to immobilization stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to water deprivation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    low-density lipoprotein receptor-related protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106217.2 → NP_001099687.2  low-density lipoprotein receptor-related protein 11 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      Conserved Domains (3) summary
      smart00765
      Location:68 → 171
      MANEC; The MANEC domain, formerly called MANSC
      cd00112
      Location:293 → 327
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00146
      Location:191 → 279
      PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      3868665..3928513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282919.1 → XP_063138989.1  low-density lipoprotein receptor-related protein 11 isoform X6

      UniProtKB/TrEMBL
      A6JP08

    2. XM_039103574.2 → XP_038959502.1  low-density lipoprotein receptor-related protein 11 isoform X1

      UniProtKB/TrEMBL
      F1M753
      Related
      ENSRNOP00000019181.6, ENSRNOT00000019181.7
      Conserved Domains (3) summary
      smart00765
      Location:68 → 171
      MANEC; The MANEC domain, formerly called MANSC
      cd00112
      Location:293 → 327
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00146
      Location:191 → 279
      PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

    3. XM_039103584.2 → XP_038959512.1  low-density lipoprotein receptor-related protein 11 isoform X3

      Related
      ENSRNOP00000104483.1, ENSRNOT00000127256.1
      Conserved Domains (3) summary
      smart00765
      Location:68 → 171
      MANEC; The MANEC domain, formerly called MANSC
      cd00112
      Location:293 → 327
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00146
      Location:191 → 279
      PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

    4. XM_039103592.2 → XP_038959520.1  low-density lipoprotein receptor-related protein 11 isoform X4

      Related
      ENSRNOP00000099995.1, ENSRNOT00000132755.1
      Conserved Domains (2) summary
      smart00765
      Location:68 → 171
      MANEC; The MANEC domain, formerly called MANSC
      cd00146
      Location:191 → 279
      PKD; polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is ...

    5. XM_063282917.1 → XP_063138987.1  low-density lipoprotein receptor-related protein 11 isoform X5

    6. XM_063282916.1 → XP_063138986.1  low-density lipoprotein receptor-related protein 11 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

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