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    TUSC1 tumor suppressor candidate 1 [ Homo sapiens (human) ]

    Gene ID: 286319, updated on 17-Sep-2024

    Summary

    Official Symbol
    TUSC1provided by HGNC
    Official Full Name
    tumor suppressor candidate 1provided by HGNC
    Primary source
    HGNC:HGNC:31010
    See related
    Ensembl:ENSG00000198680 MIM:610529; AllianceGenome:HGNC:31010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TSG9; TSG-9; CCDC89B
    Summary
    This gene is located within the region of chromosome 9p that harbors tumor suppressor genes critical in carcinogenesis. It is an intronless gene which is downregulated in non-small-cell lung cancer and small-cell lung cancer cell lines, suggesting that it may play a role in lung tumorigenesis. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
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    Genomic context

    See TUSC1 in Genome Data Viewer
    Location:
    9p21.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (25676969..25678444, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (25687486..25688961, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (25676967..25678442, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375996 Neighboring gene uncharacterized LOC105375997 Neighboring gene long intergenic non-protein coding RNA 1241 Neighboring gene Sharpr-MPRA regulatory region 6427 Neighboring gene GARIN3 pseudogene 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of sleep habits and insomnia.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study identifies candidate genes for male fertility traits in humans.
    EBI GWAS Catalog
    Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
    EBI GWAS Catalog
    Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
    EBI GWAS Catalog
    Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    tumor suppressor candidate gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012031.1 RefSeqGene

      Range
      5415..6890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004125.3NP_001004125.2  tumor suppressor candidate gene 1 protein

      Status: REVIEWED

      Source sequence(s)
      AL590322
      Consensus CDS
      CCDS34999.2
      UniProtKB/Swiss-Prot
      A0PJ78, Q2TAM9, Q67GI3, Q86SS1, Q8TAH8
      Related
      ENSP00000350716.4, ENST00000358022.6
      Conserved Domains (1) summary
      cl19252
      Location:61115
      MreC; rod shape-determining protein MreC

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      25676969..25678444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      25687486..25688961 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)