SIKE1 suppressor of IKBKE 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SIKE1provided by HGNC
Official Full Name: suppressor of IKBKE 1provided by HGNC
Primary source: HGNC:HGNC:26119
See related: Ensembl:ENSG00000052723 MIM:611656; AllianceGenome:HGNC:26119
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SIKE
Summary: SIKE interacts with IKK-epsilon (IKBKE; MIM 605048) and TBK1 (MIM 604834) and acts as a suppressor of TLR3 (MIM 603029) and virus-triggered interferon activation pathways (Huang et al., 2005 [PubMed 16281057]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in thyroid (RPKM 7.5), lymph node (RPKM 7.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p13.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (114769479..114780685, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (114780904..114792111, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (115312100..115323306, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mRNA expression of individual inhibitory kappaB kinases and SIKE are associated with unique prognostic significance and may act as valuable prognostic biomarkers and potential targets for future therapeutic interventions in gastric cancer.
Title: Prognostic values of inhibitory κB kinases mRNA expression in human gastric cancer.
SIKE, a negative regulator of the interferon pathway, attenuates pathological cardiac hypertrophy.
Title: Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy.
Data indicate that suppressor of IKKepsilon (SIKE) inhibits TANK-binding kinase 1 (TBK1)-mediated phosphorylation of interferon regulatory factor 3 (IRF3), which is essential to type I interferon production.
Title: Mechanism of endogenous regulation of the type I interferon response by suppressor of IκB kinase epsilon (SIKE), a novel substrate of TANK-binding kinase 1 (TBK1).
Overexpression of SIKE inhibits virus- and Toll-like receptor 3-triggered interferon-stimulated response elements (ISRE) but not NF-kappa B activation.
Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2560 (e-PCR)
- UniSTS:37928

RH66176 (e-PCR)
- UniSTS:91455

D15S1477 (e-PCR)
- UniSTS:474482

SHGC-75357 (e-PCR)
- UniSTS:75920

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of hippo signaling	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: suppressor of IKBKE 1

Names: suppressor of IKK epsilon

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001102396.2 → NP_001095866.1 suppressor of IKBKE 1 isoform 1

See identical proteins and their annotated locations for NP_001095866.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AI039175, AL096773, BC005934, CR749219, DA950119

Consensus CDS

CCDS41371.1

UniProtKB/Swiss-Prot

Q9BRV8

Related

ENSP00000358541.5, ENST00000369528.9

Conserved Domains (1) summary

pfam05769
Location:2 → 191

DUF837; Protein of unknown function (DUF837)
NM_025073.3 → NP_079349.2 suppressor of IKBKE 1 isoform 2

See identical proteins and their annotated locations for NP_079349.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, which results in a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AI039175, AL096773, BC005934, DA950119

Consensus CDS

CCDS878.1

UniProtKB/Swiss-Prot

Q5TEZ7, Q5TEZ9, Q68DZ4, Q9BRV8, Q9H778

Related

ENSP00000060969.6, ENST00000060969.6

Conserved Domains (1) summary

pfam05769
Location:2 → 187

SIKE; SIKE family

RNA

NR_049741.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, compared to variant 1, which results in a frameshift and an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AL096773, CR936771, DB459255
NR_049742.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) has multiple differences in the 5' coding region, compared to variant 1, which result in a frameshift and an early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AI221103, AL096773, CR936771