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Bad BCL2-associated agonist of cell death [ Rattus norvegicus (Norway rat) ]

Gene ID: 64639, updated on 2-Nov-2024

Summary

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Symbol: Badprovided by RGD
Full Name: BCL2-associated agonist of cell deathprovided by RGD
Primary source: RGD:620103
See related: EnsemblRapid:ENSRNOG00000021147 AllianceGenome:RGD:620103
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bad_v1; Bad_v2
Summary: Enables 14-3-3 protein binding activity; protein kinase B binding activity; and protein phosphatase 2B binding activity. Involved in several processes, including cellular response to chromate; positive regulation of granulosa cell apoptotic process; and response to benzene. Predicted to be located in mitochondrial outer membrane. Predicted to be part of BAD-BCL-2 complex. Predicted to be active in cytosol and mitochondrion. Used to study several diseases, including Parkinsonism; diabetic neuropathy; gastric ulcer; impotence; and middle cerebral artery infarction. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); brain disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic cancer. Orthologous to human BAD (BCL2 associated agonist of cell death). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 91.8), Brain (RPKM 86.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Bad in Genome Data Viewer

Location:: 1q43

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (213562719..213572034)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (204133502..204142829)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (222198516..222207459)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Super-resolution microscopy reveals that Na(+)/K(+)-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad.
Title: Super-resolution microscopy reveals that Na(+)/K(+)-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad.
On day 14 after hyperthermia changes in synthesis led to a decrease in Bcl-2/Bad index, which attested to weakening of the antiapoptotic defense and activation of oocyte apoptosis by the mitochondrial pathway.
Title: Expression of Apoptosis Regulator Proteins Bcl-2 and Bad in Rat Ovarian Follicular Apparatus during Recovery after Extreme Hypothermia.
it was found that NGF promoted phosphorylation of Akt and Bad, which is TrkA dependent. However, K252a and MK-2206 (TrkA and Akt inhibitor, respectively) suppressed the anti-apoptosis of NGF, indicating the protective effect of NGF on BMSCs apoptosis via a novel Akt/Bad pathway.
Title: NGF protects bone marrow mesenchymal stem cells against 2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal pathway.
Chrysin prevents apoptosis by upregulating the Bcl-2 mRNA expression and downregulating the pro-apoptotic (Bax, Bad) mRNAs in 3-nitropropionic acid induced behavioral despair/mitochondrial dysfunction/striatal apoptosis.
Title: Chrysin exerts neuroprotective effects against 3-Nitropropionic acid induced behavioral despair-Mitochondrial dysfunction and striatal apoptosis via upregulating Bcl-2 gene and downregulating Bax-Bad genes in male wistar rats.
By downregulating ATX-induced activation of Akt/Bad.
Title: Astaxanthin alleviates early brain injury following subarachnoid hemorrhage in rats: possible involvement of Akt/bad signaling.
OEC transplantation could effectively improve neurological deficits in TBI rats; the underlying mechanism may be related with their effects on neuroprotection and regeneration induction
Title: Transplantation of olfactory ensheathing cells promotes the recovery of neurological functions in rats with traumatic brain injury associated with downregulation of Bad.
The early inactivation of PKCepsilon in the ventricle may affect the mitochondrial translocation of Bad and subsequent mitochondrial disruption and apoptosis at late sepsis
Title: Early inactivation of PKCε associates with late mitochondrial translocation of Bad and apoptosis in ventricle of septic rat.
p38MAPK suppresses chronic pancreatitis by upregulating HSP27 expression and downregulating BAD expression.
Title: p38MAPK suppresses chronic pancreatitis by regulating HSP27 and BAD expression.
The protective mechanisms of fused combination FNK protein therapy might involve the inhibition of apoptotic pathways through caspase-12, but not through Bcl-2.
Title: Mild hypothermia enhanced the protective effect of protein therapy with transductive anti-death FNK protein using a rat focal transient cerebral ischemia model.
The decrease in DA content in the striatum may correlate with the abnormal behavior in elderly rats, which could be ascribed to the variations in Bad and Bcl-2.
Title: Dopamine content in the striatum and expression changes of Bad and Bcl-2 in elderly rats with abnormal behavior.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134341 (e-PCR)
- UniSTS:217623

AW530352 (e-PCR)
- UniSTS:244521

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase B binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2B binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ADP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ADP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ADP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
involved_in activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to chromate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipid	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipid	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nicotine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway in absence of ligand	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in glucose catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pore complex assembly	IEA Inferred from Electronic Annotation more info
involved_in pore complex assembly	ISO Inferred from Sequence Orthology more info
involved_in pore complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glucokinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of granulosa cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane potential	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitochondrial membrane potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type B pancreatic cell development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type B pancreatic cell development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type B pancreatic cell development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial membrane permeability	IEA Inferred from Electronic Annotation more info
involved_in regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability	ISS Inferred from Sequence or Structural Similarity more info
involved_in release of cytochrome c from mitochondria	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of cytochrome c from mitochondria	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in response to amino acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to benzene	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucose	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oleic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to progesterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in type B pancreatic cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in type B pancreatic cell proliferation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of BAD-BCL-2 complex	IEA Inferred from Electronic Annotation more info
part_of BAD-BCL-2 complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bcl2-associated agonist of cell death

Names: Bcl2-antagonist of cell death; bcl-2 associated death agonist; bcl-2-binding component 6; bcl-xL/Bcl-2-associated death promoter; bcl2 antagonist of cell death; bcl2-associated death promoter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022698.2 → NP_073189.1 bcl2-associated agonist of cell death

See identical proteins and their annotated locations for NP_073189.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

O35147, O70256, Q9JHX1

UniProtKB/TrEMBL

A0A8I6AQN1, A6HZK1

Related

ENSRNOP00000096573.2, ENSRNOT00000101503.2

Conserved Domains (1) summary

pfam10514
Location:43 → 205

Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

213562719..213572034

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039089714.2 → XP_038945642.1 bcl2-associated agonist of cell death isoform X2

UniProtKB/TrEMBL

A0A8L2UKI4

Related

ENSRNOP00000028712.4, ENSRNOT00000028712.7

Conserved Domains (1) summary

pfam10514
Location:73 → 235

Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD
XM_006230896.5 → XP_006230958.2 bcl2-associated agonist of cell death isoform X1

UniProtKB/TrEMBL

A6HZK0

Conserved Domains (1) summary

pfam10514
Location:73 → 195

Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD
XM_063272784.1 → XP_063128854.1 bcl2-associated agonist of cell death isoform X4
XM_006230897.5 → XP_006230959.1 bcl2-associated agonist of cell death isoform X3

UniProtKB/TrEMBL

A6HZK0

Conserved Domains (1) summary

pfam10514
Location:1 → 123

Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD
XM_006230898.5 → XP_006230960.1 bcl2-associated agonist of cell death isoform X5

Conserved Domains (1) summary

pfam10514
Location:1 → 163

Bcl-2_BAD; Pro-apoptotic Bcl-2 protein, BAD