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    RPC10 DNA-directed RNA polymerase core subunit RPC10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856547, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RPC10
    Official Full Name
    DNA-directed RNA polymerase core subunit RPC10
    Primary source
    SGD:S000001185
    Locus tag
    YHR143W-A
    See related
    AllianceGenome:SGD:S000001185; FungiDB:YHR143W-A; VEuPathDB:YHR143W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPB12
    Summary
    Enables zinc ion binding activity. Contributes to 5'-3' RNA polymerase activity. Involved in tRNA transcription by RNA polymerase III; transcription by RNA polymerase I; and transcription by RNA polymerase II. Located in peroxisome. Part of RNA polymerase I complex; RNA polymerase II, core complex; and RNA polymerase III complex. Orthologous to human POLR2K (RNA polymerase II, I and III subunit K). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RPC10 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (387233..387445)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Chs7p Neighboring gene Dse2p Neighboring gene deoxycytidine monophosphate deaminase Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RPC10 encodes a new mini subunit shared by yeast nuclear RNA polymerases. Treich I, et al. Gene Expr, 1992. PMID 1617300, Free PMC Article
    2. ThrRS-Mediated Translation Regulation of the RNA Polymerase III Subunit RPC10 Occurs through an Element with Similarity to Cognate tRNA ASL and Affects tRNA Levels. Levi O, et al. Genes (Basel), 2023 Feb 10. PMID 36833389, Free PMC Article
    3. Molecular Structures of Transcribing RNA Polymerase I. Tafur L, et al. Mol Cell, 2016 Dec 15. PMID 27867008, Free PMC Article
    4. Two additional common subunits, ABC10 alpha and ABC10 beta, are shared by yeast RNA polymerases. Carles C, et al. J Biol Chem, 1991 Dec 15. PMID 1748681
    5. [Molecular cloning and characterization of cDNA of the rpc10+ gene encoding the smallest subunit of nuclear RNA polymerases of Schizosaccharomyces pombe]. Shpakovskiĭ GV, et al. Bioorg Khim, 1997 May. PMID 9290054

    See all (132) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ThrRS-Mediated Translation Regulation of the RNA Polymerase III Subunit RPC10 Occurs through an Element with Similarity to Cognate tRNA ASL and Affects tRNA Levels.
      Title: ThrRS-Mediated Translation Regulation of the RNA Polymerase III Subunit RPC10 Occurs through an Element with Similarity to Cognate tRNA ASL and Affects tRNA Levels.
    2. Molecular structure of transcribing RNA polymerase I has been presented.
      Title: Molecular Structures of Transcribing RNA Polymerase I.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase I activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase II activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA-dependent RNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in RNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA transcription by RNA polymerase III IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase III IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase II, core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II, core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase core subunit RPC10
    NP_012013.1
    • RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress; localizes to the peroxisome in a Pex5p-dependent manner

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      387233..387445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179273.1 → NP_012013.1  TPA: DNA-directed RNA polymerase core subunit RPC10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012013.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL93, P40422
      UniProtKB/TrEMBL
      A6ZT52, B3LSQ8, C7GXW4, C8Z9U1, G2WFL7, N1P4S0
      Conserved Domains (1) summary
      smart00659
      Location:27 → 70
      RPOLCX; RNA polymerase subunit CX
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40422.1

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