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    TCEAL4 transcription elongation factor A like 4 [ Homo sapiens (human) ]

    Gene ID: 79921, updated on 3-Nov-2024

    Summary

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    Official Symbol
    TCEAL4provided by HGNC
    Official Full Name
    transcription elongation factor A like 4provided by HGNC
    Primary source
    HGNC:HGNC:26121
    See related
    Ensembl:ENSG00000133142 AllianceGenome:HGNC:26121
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WEX7; NPD017
    Summary
    This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 91.3), endometrium (RPKM 75.4) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See TCEAL4 in Genome Data Viewer
    Location:
    Xq22.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103576231..103587729)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102023219..102034716)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102831159..102842657)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LL0XNC01-250H12.3 Neighboring gene RAB40A, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29820 Neighboring gene long intergenic non-protein coding RNA 2589 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:102809676-102810875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102840363-102841076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29821 Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29823 Neighboring gene transcription elongation factor A like 3 Neighboring gene transcription elongation factor A like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of transcription elogation factor A (SII) like 4 (TCEAL4) in anaplastic thyroid cancer. Akaishi J, et al. BMC Cancer, 2006 Nov 1. PMID 17076909, Free PMC Article
    2. [Cloning of human B lymphocyte activation-related novel gene]. Lu XW, et al. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2001 Feb. PMID 12905813
    3. USP9X deubiquitinates and stabilizes CDC123 to promote breast carcinogenesis through regulating cell cycle. Song N, et al. Mol Carcinog, 2023 Oct. PMID 37314216
    4. Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. Ohira M, et al. Oncogene, 2003 Aug 21. PMID 12934113
    5. Identification and Characterization of USP7 Targets in Cancer Cells. Georges A, et al. Sci Rep, 2018 Oct 26. PMID 30367141, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ21174, DKFZp686M0279

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription elongation factor A protein-like 4
    Names
    TCEA-like protein 4
    epididymis secretory sperm binding protein
    transcription elongation factor A (SII)-like 4
    transcription elongation factor S-II protein-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016315.2 RefSeqGene

      Range
      14285..16499
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001006935.3 → NP_001006936.1  transcription elongation factor A protein-like 4 isoform 1

      See identical proteins and their annotated locations for NP_001006936.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AF271783
      Consensus CDS
      CCDS14510.2
      UniProtKB/Swiss-Prot
      Q8WY12, Q96EI5, Q9H2H1, Q9H775
      UniProtKB/TrEMBL
      A0A384NKK0, A2RQR6
      Related
      ENSP00000421156.1, ENST00000472484.6
      Conserved Domains (2) summary
      pfam04538
      Location:88 → 190
      BEX; Brain expressed X-linked like family
      cl27511
      Location:7 → 154
      Na_Ca_ex; Sodium/calcium exchanger protein

    2. NM_001006937.3 → NP_001006938.1  transcription elongation factor A protein-like 4 isoform 1

      See identical proteins and their annotated locations for NP_001006938.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two alternate splice sites in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AF314542, AI879651, BP375855
      Consensus CDS
      CCDS14510.2
      UniProtKB/Swiss-Prot
      Q8WY12, Q96EI5, Q9H2H1, Q9H775
      UniProtKB/TrEMBL
      A0A384NKK0, A2RQR6
      Related
      ENSP00000427494.1, ENST00000494801.5
      Conserved Domains (2) summary
      pfam04538
      Location:88 → 190
      BEX; Brain expressed X-linked like family
      cl27511
      Location:7 → 154
      Na_Ca_ex; Sodium/calcium exchanger protein

    3. NM_001300901.2 → NP_001287830.1  transcription elongation factor A protein-like 4 isoform 2

      See identical proteins and their annotated locations for NP_001287830.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains multiple alternate exons in the 5' region, uses an alternate internal splice site, and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1.
      Source sequence(s)
      AF271783, AF314542, BX104938
      Consensus CDS
      CCDS76004.1
      UniProtKB/Swiss-Prot
      Q96EI5
      Related
      ENSP00000361712.4, ENST00000372629.4
      Conserved Domains (1) summary
      pfam04538
      Location:231 → 333
      BEX; Brain expressed X-linked like family

    4. NM_001305840.2 → NP_001292769.1  transcription elongation factor A protein-like 4 isoform 1

      See identical proteins and their annotated locations for NP_001292769.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice site and contains an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AF314542, AI879651, AL833640, AU253367
      Consensus CDS
      CCDS14510.2
      UniProtKB/Swiss-Prot
      Q8WY12, Q96EI5, Q9H2H1, Q9H775
      UniProtKB/TrEMBL
      A0A384NKK0, A2RQR6
      Related
      ENSP00000424314.1, ENST00000472745.1
      Conserved Domains (2) summary
      pfam04538
      Location:88 → 190
      BEX; Brain expressed X-linked like family
      cl27511
      Location:7 → 154
      Na_Ca_ex; Sodium/calcium exchanger protein

    5. NM_001305841.2 → NP_001292770.1  transcription elongation factor A protein-like 4 isoform 1

      See identical proteins and their annotated locations for NP_001292770.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) uses two alternate splice sites and lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AF314542, AI879651, BI084326
      Consensus CDS
      CCDS14510.2
      UniProtKB/Swiss-Prot
      Q8WY12, Q96EI5, Q9H2H1, Q9H775
      UniProtKB/TrEMBL
      A0A384NKK0, A2RQR6
      Related
      ENSP00000415564.2, ENST00000415568.2
      Conserved Domains (2) summary
      pfam04538
      Location:88 → 190
      BEX; Brain expressed X-linked like family
      cl27511
      Location:7 → 154
      Na_Ca_ex; Sodium/calcium exchanger protein

    6. NM_001305842.2 → NP_001292771.1  transcription elongation factor A protein-like 4 isoform 1

      See identical proteins and their annotated locations for NP_001292771.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AF314542, AI879651, AL833640, BF359447
      Consensus CDS
      CCDS14510.2
      UniProtKB/Swiss-Prot
      Q8WY12, Q96EI5, Q9H2H1, Q9H775
      UniProtKB/TrEMBL
      A0A384NKK0, A2RQR6
      Conserved Domains (2) summary
      pfam04538
      Location:88 → 190
      BEX; Brain expressed X-linked like family
      cl27511
      Location:7 → 154
      Na_Ca_ex; Sodium/calcium exchanger protein

    7. NM_024863.6 → NP_079139.4  transcription elongation factor A protein-like 4 isoform 1

      See identical proteins and their annotated locations for NP_079139.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 2, 4, 6, 7, and 8 encode the same isoform (1).
      Source sequence(s)
      AI879651, AL833640
      Consensus CDS
      CCDS14510.2
      UniProtKB/Swiss-Prot
      Q8WY12, Q96EI5, Q9H2H1, Q9H775
      UniProtKB/TrEMBL
      A0A384NKK0, A2RQR6
      Related
      ENSP00000421857.1, ENST00000468024.5
      Conserved Domains (2) summary
      pfam04538
      Location:88 → 190
      BEX; Brain expressed X-linked like family
      cl27511
      Location:7 → 154
      Na_Ca_ex; Sodium/calcium exchanger protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      103576231..103587729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017029856.2 → XP_016885345.1  transcription elongation factor A protein-like 4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      102023219..102034716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327906.1 → XP_054183881.1  transcription elongation factor A protein-like 4 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001006936.1: Suppressed sequence

      Description
      NM_001006936.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support the use of a non-consensus splice site in the 5' UTR.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96EI5.2 GenPept UniProtKB/Swiss-Prot:Q96EI5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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