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    ANAPC10 anaphase promoting complex subunit 10 [ Homo sapiens (human) ]

    Gene ID: 10393, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ANAPC10provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 10provided by HGNC
    Primary source
    HGNC:HGNC:24077
    See related
    Ensembl:ENSG00000164162 MIM:613745; AllianceGenome:HGNC:24077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOC1; APC10
    Summary
    ANAPC10 is a core subunit of the anaphase-promoting complex (APC), or cyclosome, a ubiquitin protein ligase that is essential for progression through the cell cycle. APC initiates sister chromatid separation by ubiquitinating the anaphase inhibitor securin (PTTG1; MIM 604147) and triggers exit from mitosis by ubiquitinating cyclin B (CCNB1; MIM 123836), the activating subunit of cyclin-dependent kinase-1 (CDK1; MIM 116940) (summary by Wendt et al., 2001 [PubMed 11524682]).[supplied by OMIM, Feb 2011]
    Expression
    Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ANAPC10 in Genome Data Viewer
    Location:
    4q31.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (144994575..145098571, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (148311947..148415963, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (145915727..146019723, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900792 Neighboring gene uncharacterized LOC124900793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15722 Neighboring gene RN7SK pseudogene 235 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:146018722-146019921 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21962 Neighboring gene ATP binding cassette subfamily E member 1 Neighboring gene OTU deubiquitinase 4 Neighboring gene MPRA-validated peak5130 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21963 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146100843-146101672 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:146101673-146102502 Neighboring gene uncharacterized LOC124900794

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex. Wendt KS, et al. Nat Struct Biol, 2001 Sep. PMID 11524682
    2. A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer. Wang Y, et al. Cell Cycle, 2019 May. PMID 31023143, Free PMC Article
    3. Identification of human APC10/Doc1 as a subunit of anaphase promoting complex. Kurasawa Y, et al. Oncogene, 1999 Sep 16. PMID 10498862
    4. The APC10 subunit of the anaphase-promoting complex/cyclosome orchestrates NLRP3 inflammasome activation during the cell cycle. Huang S, et al. FEBS Lett, 2021 Oct. PMID 34407203
    5. Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1. Nourry C, et al. BMC Cell Biol, 2004 May 16. PMID 15144564, Free PMC Article

    See all (83) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. APC10 was overexpressed in non-small cell lung cancer cell lines compared to human bronchial epithelial cell lines. APC10 was shown to interact with GAC; knocking down APC10 downregulated glutamine metabolism to induce autophagy, resulting in effective inhibition of the proliferation and migration of non-small cell lung cancer cells.
      Title: A novel function of anaphase promoting complex subunit 10 in tumor progression in non-small cell lung cancer.
    2. Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
      Title: How APC/C-Cdc20 changes its substrate specificity in mitosis.
    3. Substrates are recruited to the Anaphase-promoting complex by binding to a bipartite substrate receptor composed of Cdh1 and Doc1.
      Title: Substrate binding on the APC/C occurs between the coactivator Cdh1 and the processivity factor Doc1.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp564L0562

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein branched polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 10
    Names
    cyclosome subunit 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256706.2 → NP_001243635.1  anaphase-promoting complex subunit 10 isoform 1

      See identical proteins and their annotated locations for NP_001243635.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AC097649, AF132794, AL080090, BF693880, BU175327
      Consensus CDS
      CCDS43273.1
      UniProtKB/Swiss-Prot
      D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
      UniProtKB/TrEMBL
      D6RA92
      Related
      ENSP00000423995.1, ENST00000507656.6
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    2. NM_001256707.2 → NP_001243636.1  anaphase-promoting complex subunit 10 isoform 1

      See identical proteins and their annotated locations for NP_001243636.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AC097649, AL080090, BF693880, CV023091
      Consensus CDS
      CCDS43273.1
      UniProtKB/Swiss-Prot
      D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
      UniProtKB/TrEMBL
      D6RA92
      Related
      ENSP00000403891.2, ENST00000451299.6
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    3. NM_001256708.2 → NP_001243637.1  anaphase-promoting complex subunit 10 isoform 1

      See identical proteins and their annotated locations for NP_001243637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AC096757, AC097649, BU567906, CV023091
      Consensus CDS
      CCDS43273.1
      UniProtKB/Swiss-Prot
      D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
      UniProtKB/TrEMBL
      D6RA92
      Related
      ENSP00000478501.1, ENST00000613466.4
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    4. NM_001256709.2 → NP_001243638.1  anaphase-promoting complex subunit 10 isoform 2

      See identical proteins and their annotated locations for NP_001243638.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC097649, AL080090, BF693880, BG494966
      UniProtKB/TrEMBL
      D6RA92
      Conserved Domains (1) summary
      pfam03256
      Location:15 → 194
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    5. NM_001256710.2 → NP_001243639.1  anaphase-promoting complex subunit 10 isoform 3

      See identical proteins and their annotated locations for NP_001243639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC097649, AL080090, BF693880, CN305215
      UniProtKB/TrEMBL
      A0A3B3ISY7
      Related
      ENSP00000423223.1, ENST00000504721.5
      Conserved Domains (1) summary
      cl02148
      Location:4 → 109
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    6. NM_001256711.2 → NP_001243640.1  anaphase-promoting complex subunit 10 isoform 3

      See identical proteins and their annotated locations for NP_001243640.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and includes an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. Variants 6 and 7 encode the same isoform (3), which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC097649, BF693880, BG530912, CN305215
      UniProtKB/TrEMBL
      A0A3B3ISY7
      Conserved Domains (1) summary
      cl02148
      Location:4 → 109
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    7. NM_001256712.2 → NP_001243641.1  anaphase-promoting complex subunit 10 isoform 4

      See identical proteins and their annotated locations for NP_001243641.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate splice site in the 5' UTR and lacks an exon in the coding region, which results in a frameshift, compared to variant 1. The encoded isoform (4) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC097649, AV757106, BF693880
      UniProtKB/TrEMBL
      D6RB36
      Conserved Domains (1) summary
      cl02148
      Location:4 → 69
      APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination

    8. NM_001318367.2 → NP_001305296.1  anaphase-promoting complex subunit 10 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10) contains an alternate 5' terminal exon compared to variant 1. This difference results in a distinct 5' UTR, translation initiation at an alternate start codon, and a novel 5' coding region compared to variant 1. The encoded isoform (5) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB012109, AC096757, AC097649, AW025455, BI913723
      UniProtKB/Swiss-Prot
      Q9UM13
      Conserved Domains (1) summary
      pfam03256
      Location:38 → 217
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    9. NM_014885.5 → NP_055700.2  anaphase-promoting complex subunit 10 isoform 1

      See identical proteins and their annotated locations for NP_055700.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
      Source sequence(s)
      AB012109, AC097649
      Consensus CDS
      CCDS43273.1
      UniProtKB/Swiss-Prot
      D3DNZ7, Q2V500, Q9UG51, Q9UM13, Q9Y5R0
      UniProtKB/TrEMBL
      D6RA92
      Related
      ENSP00000310071.5, ENST00000309439.9
      Conserved Domains (1) summary
      pfam03256
      Location:4 → 183
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    RNA

    1. NR_046345.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC097649, BF693880, BI488888

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      144994575..145098571 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531531.4 → XP_011529833.2  anaphase-promoting complex subunit 10 isoform X8

      Related
      ENSP00000424463.1, ENST00000502847.1

    2. XM_047449503.1 → XP_047305459.1  anaphase-promoting complex subunit 10 isoform X2

    3. XM_047449507.1 → XP_047305463.1  anaphase-promoting complex subunit 10 isoform X9

    4. XM_047449502.1 → XP_047305458.1  anaphase-promoting complex subunit 10 isoform X1

    5. XM_047449504.1 → XP_047305460.1  anaphase-promoting complex subunit 10 isoform X2

    6. XM_017007639.3 → XP_016863128.1  anaphase-promoting complex subunit 10 isoform X1

      Conserved Domains (1) summary
      pfam03256
      Location:38 → 217
      ANAPC10; Anaphase-promoting complex, subunit 10 (APC10)

    7. XM_011531525.3 → XP_011529827.2  anaphase-promoting complex subunit 10 isoform X3

    8. XM_017007642.2 → XP_016863131.1  anaphase-promoting complex subunit 10 isoform X6

    9. XM_017007641.2 → XP_016863130.1  anaphase-promoting complex subunit 10 isoform X4

    10. XM_047449505.1 → XP_047305461.1  anaphase-promoting complex subunit 10 isoform X5

      UniProtKB/TrEMBL
      D6RD74
      Related
      ENSP00000425459.1, ENST00000512680.5

    11. XM_047449506.1 → XP_047305462.1  anaphase-promoting complex subunit 10 isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      148311947..148415963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348736.1 → XP_054204711.1  anaphase-promoting complex subunit 10 isoform X8

    2. XM_054348729.1 → XP_054204704.1  anaphase-promoting complex subunit 10 isoform X2

    3. XM_054348737.1 → XP_054204712.1  anaphase-promoting complex subunit 10 isoform X9

    4. XM_054348727.1 → XP_054204702.1  anaphase-promoting complex subunit 10 isoform X1

    5. XM_054348730.1 → XP_054204705.1  anaphase-promoting complex subunit 10 isoform X2

    6. XM_054348728.1 → XP_054204703.1  anaphase-promoting complex subunit 10 isoform X1

    7. XM_054348731.1 → XP_054204706.1  anaphase-promoting complex subunit 10 isoform X3

    8. XM_054348734.1 → XP_054204709.1  anaphase-promoting complex subunit 10 isoform X6

    9. XM_054348732.1 → XP_054204707.1  anaphase-promoting complex subunit 10 isoform X4

    10. XM_054348733.1 → XP_054204708.1  anaphase-promoting complex subunit 10 isoform X5

      UniProtKB/TrEMBL
      D6RD74

    11. XM_054348735.1 → XP_054204710.1  anaphase-promoting complex subunit 10 isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UM13.1 GenPept UniProtKB/Swiss-Prot:Q9UM13

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