PRXL2A peroxiredoxin like 2A [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRXL2Aprovided by HGNC
Official Full Name: peroxiredoxin like 2Aprovided by HGNC
Primary source: HGNC:HGNC:28651
See related: Ensembl:ENSG00000122378 MIM:617165; AllianceGenome:HGNC:28651
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Adrx; PAMM; FAM213A; C10orf58
Summary: Enables antioxidant activity. Involved in regulation of osteoclast differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in fat (RPKM 75.6), brain (RPKM 14.4) and 16 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (80407829..80437115)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (81276927..81306214)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (82167585..82196871)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FAM213A is linked to prognostic significance in acute myeloid leukemia through regulation of oxidative stress and myelopoiesis.
Title: FAM213A is linked to prognostic significance in acute myeloid leukemia through regulation of oxidative stress and myelopoiesis.
this study has pinpointed novel clues demonstrating that downregulation of miR-125b suppressor underlies upregulation of PRXL2A in OSCC, and this then protects the affected tumor cells from oxidative stress.
Title: miR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A.
Antioxidant stress induces PAMM mRNA expression in human peripheral blood mononuclear cells .
Title: A short report: PAMM, a novel antioxidant protein, induced by oxidative stress.
results suggest that adipocyte-derived PAMM may suppress macrophage activation by inhibiting MAPK signalling pathway.
Title: Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling.
The PAMM is a redox regulatory protein that modulates osteoclast differentiation in vitro. PAMM expression may affect bone resorption in vivo and help to maintain bone mass.
Title: PAMM: a redox regulatory protein that modulates osteoclast differentiation.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH92421 (e-PCR)
- UniSTS:92946

GDB:434012 (e-PCR)
- UniSTS:157204

D8S2279 (e-PCR)
- UniSTS:473907

A005D17 (e-PCR)
- UniSTS:63315

D15S1477 (e-PCR)
- UniSTS:474482

RH80030 (e-PCR)
- UniSTS:87680

D11S3114 (e-PCR)
- UniSTS:152207

D10S240E (e-PCR)
- UniSTS:147347

STS-AA041282 (e-PCR)
- UniSTS:34986

GDB:335751 (e-PCR)
- UniSTS:156601

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables antioxidant activity	IBA Inferred from Biological aspect of Ancestor more info
enables antioxidant activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in regulation of osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: peroxiredoxin-like 2A

Names: Adiporedoxin; UPF0765 protein C10orf58; family with sequence similarity 213 member A; peroxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytes; peroxiredoxin-like 2 activated in M-CSF stimulated monocytes; redox-regulatory protein FAM213A; redox-regulatory protein PAMM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001243778.2 → NP_001230707.1 peroxiredoxin-like 2A isoform 1 precursor

See identical proteins and their annotated locations for NP_001230707.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).

Source sequence(s)

AA829725, AC021028, AL359195, BC005871

Consensus CDS

CCDS7368.1

UniProtKB/Swiss-Prot

B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8

Related

ENSP00000361261.5, ENST00000372187.9

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001243779.2 → NP_001230708.1 peroxiredoxin-like 2A isoform 1 precursor

See identical proteins and their annotated locations for NP_001230708.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1)

Source sequence(s)

AA829725, AC021028, AF305824, BC005871, BE742158

Consensus CDS

CCDS7368.1

UniProtKB/Swiss-Prot

B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8

Related

ENSP00000361262.1, ENST00000372188.5

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001243780.2 → NP_001230709.1 peroxiredoxin-like 2A isoform 1 precursor

See identical proteins and their annotated locations for NP_001230709.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).

Source sequence(s)

AA829725, AC021028, BC024308, DB494833

Consensus CDS

CCDS7368.1

UniProtKB/Swiss-Prot

B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8

Related

ENSP00000478152.1, ENST00000615554.4

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001243781.2 → NP_001230710.1 peroxiredoxin-like 2A isoform 2 precursor

See identical proteins and their annotated locations for NP_001230710.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AA829725, AC021028, AK075447, BC005871

Consensus CDS

CCDS58089.1

UniProtKB/Swiss-Prot

Q9BRX8

Related

ENSP00000361259.1, ENST00000372185.5

Conserved Domains (1) summary

cd02970
Location:37 → 190

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_001243782.2 → NP_001230711.1 peroxiredoxin-like 2A isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, uses an alternate splice site and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AA829725, AC021028, AL359195, BC005871, CN396006

UniProtKB/Swiss-Prot

Q9BRX8

Conserved Domains (1) summary

cd02970
Location:44 → 197

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
NM_032333.5 → NP_115709.3 peroxiredoxin-like 2A isoform 1 precursor

See identical proteins and their annotated locations for NP_115709.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, 3 and 4 encode the same isoform.

Source sequence(s)

AA829725, AC021028, AI589570, AK074643, BC071938

Consensus CDS

CCDS7368.1

UniProtKB/Swiss-Prot

B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8

Related

ENSP00000482445.1, ENST00000606162.6

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

80407829..80437115

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011540266.3 → XP_011538568.1 peroxiredoxin-like 2A isoform X2

See identical proteins and their annotated locations for XP_011538568.1

UniProtKB/Swiss-Prot

B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
XM_017016775.2 → XP_016872264.1 peroxiredoxin-like 2A isoform X1

Conserved Domains (1) summary

cd02970
Location:55 → 208

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...
XM_011540265.3 → XP_011538567.1 peroxiredoxin-like 2A isoform X2

See identical proteins and their annotated locations for XP_011538567.1

UniProtKB/Swiss-Prot

B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8

Conserved Domains (1) summary

cd02970
Location:48 → 201

PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...