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    ste6 guanyl-nucleotide exchange factor Ste6 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538724, updated on 17-May-2024

    Summary

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    Gene symbol
    ste6
    Gene description
    guanyl-nucleotide exchange factor Ste6
    Primary source
    FungiDB:SPCC1442.01
    Locus tag
    SPCC1442.01
    See related
    VEuPathDB:SPCC1442.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPCC1450.17
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    Genomic context

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    See ste6 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1765913..1768971)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ER protein folding oxidoreductin Ero1b Neighboring gene putative pig-F family GPI synthesis protein Neighboring gene putative triacylglycerol lipase Neighboring gene miscRNA Neighboring gene putative central kinetochore-associated family protein Neighboring gene putative ATP-Mg/Pi carrier protein Neighboring gene putative meiotic recombination protein Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Homologous activators of ras in fission and budding yeast. Hughes DA, et al. Nature, 1990 Mar 22. PMID 2107403
    2. Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors. Papadaki P, et al. Mol Cell Biol, 2002 Jul. PMID 12052869, Free PMC Article
    3. Inhibition of Ras activity coordinates cell fusion with cell-cell contact during yeast mating. Merlini L, et al. J Cell Biol, 2018 Apr 2. PMID 29453312, Free PMC Article
    4. Promoter nucleosome dynamics regulated by signalling through the CTD code. Materne P, et al. Elife, 2015 Jun 22. PMID 26098123, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of pheromone response MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in mating projection actin fusion focus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    guanyl-nucleotide exchange factor Ste6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1765913..1768971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023306.2 → NP_588316.1  guanyl-nucleotide exchange factor Ste6 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588316.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P26674, Q9UUM8
      Conserved Domains (3) summary
      smart00147
      Location:659 → 895
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:489 → 604
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      smart00326
      Location:7 → 55
      SH3; Src homology 3 domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    1607336A.1

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