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    RPA14 DNA-directed RNA polymerase I subunit RPA14 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851734, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPA14
    Official Full Name
    DNA-directed RNA polymerase I subunit RPA14
    Primary source
    SGD:S000002563
    Locus tag
    YDR156W
    See related
    AllianceGenome:SGD:S000002563; FungiDB:YDR156W; VEuPathDB:YDR156W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to RNA polymerase I activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Part of RNA polymerase I complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPA14 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (769525..769938)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ent5p Neighboring gene peptidylprolyl isomerase CPR1 Neighboring gene uncharacterized protein Neighboring gene aspartate-semialdehyde dehydrogenase Neighboring gene Sac3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The association of three subunits with yeast RNA polymerase is stabilized by A14. Smid A, et al. J Biol Chem, 1995 Jun 2. PMID 7768955
    2. Crystallization of RNA polymerase I subcomplex A14/A43 by iterative prediction, probing and removal of flexible regions. Geiger SR, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008 May 1. PMID 18453714, Free PMC Article
    3. Structural and functional homology between the RNAP(I) subunits A14/A43 and the archaeal RNAP subunits E/F. Meka H, et al. Nucleic Acids Res, 2003 Aug 1. PMID 12888498, Free PMC Article
    4. Generation of Fluorescent Versions of Saccharomyces cerevisiae RPA to Study the Conformational Dynamics of Its ssDNA-Binding Domains. Kuppa S, et al. Methods Mol Biol, 2021. PMID 33847957, Free PMC Article
    5. RNA polymerase III initiation on coligo DNA templates containing loops of variable sequence, size and nucleotide chemistry. Patel J, et al. Gene, 2017 May 15. PMID 27593562, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase I activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleolar large rRNA transcription by RNA polymerase I IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleolar large rRNA transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell size HMP PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase I subunit RPA14
    NP_010440.1
    • RNA polymerase I subunit A14

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      769525..769938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180463.1 → NP_010440.1  TPA: DNA-directed RNA polymerase I subunit RPA14 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010440.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSD7, P50106
      UniProtKB/TrEMBL
      A6ZYB5, B3LGC7, C7GX37, C8Z571, G2WAQ5, N1PAE4
      Conserved Domains (1) summary
      pfam08203
      Location:18 → 102
      RNA_polI_A14; Yeast RNA polymerase I subunit RPA14
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50106.1

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