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    SWM1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851847, updated on 11-Sep-2024

    Summary

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    Official Symbol
    SWM1
    Primary source
    SGD:S000002668
    Locus tag
    YDR260C
    See related
    AllianceGenome:SGD:S000002668; FungiDB:YDR260C; VEuPathDB:YDR260C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APC13
    Summary
    Contributes to ubiquitin protein ligase activity. Involved in anaphase-promoting complex assembly; ascospore wall assembly; and regulation of mitotic metaphase/anaphase transition. Located in nucleus. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (976717..977229, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene chaperone ATPase HSP78 Neighboring gene Yap6p Neighboring gene glucan exo-1,3-beta-glucosidase Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SWM1, a developmentally regulated gene, is required for spore wall assembly in Saccharomyces cerevisiae. Ufano S, et al. Mol Cell Biol, 1999 Mar. PMID 10022899, Free PMC Article
    2. Swm1p, a subunit of the APC/cyclosome, is required to maintain cell wall integrity during growth at high temperature in Saccharomyces cerevisiae. Ufano S, et al. FEMS Microbiol Lett, 2004 May 15. PMID 15135545
    3. The anaphase promoting complex contributes to the degradation of the S. cerevisiae telomerase recruitment subunit Est1p. Ferguson JL, et al. PLoS One, 2013. PMID 23372810, Free PMC Article
    4. The spindle checkpoint protein Mad2 regulates APC/C activity during prometaphase and metaphase of meiosis I in Saccharomyces cerevisiae. Tsuchiya D, et al. Mol Biol Cell, 2011 Aug 15. PMID 21697504, Free PMC Article
    5. Swm1p subunit of the APC/cyclosome is required for activation of the daughter-specific gene expression program mediated by Ace2p during growth at high temperature in Saccharomyces cerevisiae. Ufano S, et al. J Cell Sci, 2004 Feb 1. PMID 14709718

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Swm1p is required for full catalytic activity of the anaphase-promoting complex/cyclosome.
      Title: In vivo characterization of the nonessential budding yeast anaphase-promoting complex/cyclosome components Swm1p, Mnd2p and Apc9p.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore wall assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Swm1p
    NP_010546.1
    • Subunit of the anaphase-promoting complex (APC); APC is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      976717..977229 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180568.1 → NP_010546.1  TPA: Swm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010546.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSP0, Q12379
      UniProtKB/TrEMBL
      A6ZYL2, B3LG30, B5VGE4, C7GTJ5, C8Z5H2, G2WB03, N1P6Z7
      Conserved Domains (1) summary
      pfam05839
      Location:7 → 111
      Apc13p; Apc13p protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12379.1

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