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    Cdc14a cell division cycle 14A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310806, updated on 13-Jul-2024

    Summary

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    Official Symbol
    Cdc14aprovided by RGD
    Official Full Name
    cell division cycle 14Aprovided by RGD
    Primary source
    RGD:1304649
    See related
    EnsemblRapid:ENSRNOG00000014515 AllianceGenome:RGD:1304649
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    The protein encoded by this gene is a dual-specificity phosphatase that preferentially dephosphorylates cyclin dependent kinase substrates to regulate the cell cycle. In human cell lines, this protein localizes to interphase chromosomes, and depletion of the transcript results in centrosome separation and cytokinesis defects. In mouse, the protein localizes to the nucleus of prophase I arrested oocytes and then becomes dispersed in meiotically competent oocytes. Knockdown of the protein delays exit from metaphase I and results in eggs with chromosomal abnormalities and elevated aneuploidy, demonstrating a function in regulation of meiosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
    Expression
    Biased expression in Spleen (RPKM 86.9), Lung (RPKM 86.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc14a in Genome Data Viewer
    Location:
    2q42
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (206910475..207070537, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204225540..204380927, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219302577..219458345, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485676 Neighboring gene G-protein coupled receptor 88 Neighboring gene uncharacterized LOC134485677 Neighboring gene uncharacterized LOC120100925 Neighboring gene uncharacterized LOC134485678 Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene dihydrolipoamide branched chain transacylase E2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The CDC14A phosphatase regulates oocyte maturation in mouse. Schindler K, et al. Cell Cycle, 2009 Apr 1. PMID 19270517, Free PMC Article
    2. Iron regulation and the cell cycle: identification of an iron-responsive element in the 3'-untranslated region of human cell division cycle 14A mRNA by a refined microarray-based screening strategy. Sanchez M, et al. J Biol Chem, 2006 Aug 11. PMID 16760464
    3. Deregulated human Cdc14A phosphatase disrupts centrosome separation and chromosome segregation. Mailand N, et al. Nat Cell Biol, 2002 Apr. PMID 11901424
    4. CDC14A phosphatase is essential for hearing and male fertility in mouse and human. Imtiaz A, et al. Hum Mol Genet, 2018 Mar 1. PMID 29293958, Free PMC Article
    5. The writers, readers, and functions of the RNA polymerase II C-terminal domain code. Jeronimo C, et al. Chem Rev, 2013 Nov 13. PMID 23837720

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinociliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinocilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stereocilium tip ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase CDC14A
    Names
    CDC14 cell division cycle 14 homolog A
    NP_001101188.2
    NP_001128328.1
    XP_008759682.1
    XP_017446421.1
    XP_017446422.1
    XP_063138006.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107718.2 → NP_001101188.2  dual specificity protein phosphatase CDC14A isoform 2

      See identical proteins and their annotated locations for NP_001101188.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region and an alternate 3' terminal exon, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC161876
      UniProtKB/TrEMBL
      A0A8I6B415, B1WBT1, D4ABH9
      Conserved Domains (2) summary
      cd14499
      Location:163 → 336
      CDC14_C; C-terminal dual-specificity phosphatase domain of CDC14 family proteins
      cd17657
      Location:10 → 154
      CDC14_N; N-terminal domain pseudophosphatase domain of CDC14 family proteins

    2. NM_001134856.1 → NP_001128328.1  dual specificity protein phosphatase CDC14A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. It encodes isoform 1.
      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A8I5ZMT6, E9PSZ9
      Related
      ENSRNOP00000061448.2, ENSRNOT00000064735.6
      Conserved Domains (3) summary
      COG2453
      Location:175 → 329
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:17 → 152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:187 → 326
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      206910475..207070537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761460.4 → XP_008759682.1  dual specificity protein phosphatase CDC14A isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMT6
      Related
      ENSRNOP00000096339.2, ENSRNOT00000112422.2
      Conserved Domains (3) summary
      COG2453
      Location:190 → 344
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:17 → 167
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:202 → 341
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. XM_063281936.1 → XP_063138006.1  dual specificity protein phosphatase CDC14A isoform X3

      UniProtKB/TrEMBL
      A0A8I6B415

    3. XM_017590932.3 → XP_017446421.1  dual specificity protein phosphatase CDC14A isoform X1

      UniProtKB/TrEMBL
      A0A8I6B415

    4. XM_017590933.3 → XP_017446422.1  dual specificity protein phosphatase CDC14A isoform X3

      UniProtKB/TrEMBL
      A0A8I6B415
    Nucleotide Protein Strain
    Heading Accession and Version

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