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    FUN14 Fun14p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851225, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FUN14
    Official Full Name
    Fun14p
    Primary source
    SGD:S000000006
    Locus tag
    YAL008W
    See related
    AllianceGenome:SGD:S000000006; FungiDB:YAL008W; VEuPathDB:YAL008W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MCP3
    Summary
    Involved in mitochondrion organization and phospholipid homeostasis. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FUN14 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (136914..137510)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Mdm10p Neighboring gene Nem1-Spo7 phosphatase regulatory subunit SPO7 Neighboring gene Erp2p Neighboring gene tRNA-Pro

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction network of the mitochondrial outer membrane protein Mcp3. Sinzel M, et al. FEBS Lett, 2018 Oct. PMID 30192984
    2. The GET pathway can increase the risk of mitochondrial outer membrane proteins to be mistargeted to the ER. Vitali DG, et al. J Cell Sci, 2018 May 16. PMID 29661846
    3. Mcp3 is a novel mitochondrial outer membrane protein that follows a unique IMP-dependent biogenesis pathway. Sinzel M, et al. EMBO Rep, 2016 Jul. PMID 27226123, Free PMC Article
    4. Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Zahedi RP, et al. Mol Biol Cell, 2006 Mar. PMID 16407407, Free PMC Article
    5. The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. Bussey H, et al. Proc Natl Acad Sci U S A, 1995 Apr 25. PMID 7731988, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phospholipid homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Fun14p
    NP_009394.1
    • Integral mitochondrial outer membrane (MOM) protein; dosage suppressor of an MDM10 null that reduces ERMES-related phenotypes, such as alterations in mitochondrial morphology, protein complex assembly, and lipid profile; dosage suppressor of MDM12, MDM34, and MMM1 null mutant growth defects; novel mechanism of MOM import involving Tom70p, the TOM complex, and the TIM23 complex, requiring mitochondrial membrane potential and processing by the IMP complex for correct biogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      136914..137510
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178153.1 → NP_009394.1  TPA: Fun14p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009394.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPL0, P18411
      UniProtKB/TrEMBL
      A7A0G1, B3LUU5, C7GPM6, C8Z3M2, G2W8M4, N1P9U1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18411.3

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