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    SEN34 tRNA splicing endonuclease subunit SEN34 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851267, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SEN34
    Official Full Name
    tRNA splicing endonuclease subunit SEN34
    Primary source
    SGD:S000000066
    Locus tag
    YAR008W
    See related
    AllianceGenome:SGD:S000000066; FungiDB:YAR008W; VEuPathDB:YAR008W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN4
    Summary
    Enables tRNA-intron endonuclease activity. Involved in tRNA-type intron splice site recognition and cleavage. Located in mitochondrial outer membrane. Part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2C. Orthologous to human TSEN34 (tRNA splicing endonuclease subunit 34). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SEN34 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (158966..159793)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene COMPASS subunit protein SWD1 Neighboring gene replication factor A subunit protein RFA1 Neighboring gene truncated gag-pol fusion protein Neighboring gene gag protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cleavage of pre-tRNAs by the splicing endonuclease requires a composite active site. Trotta CR, et al. Nature, 2006 May 18. PMID 16710424
    2. Yeast tRNA-splicing endonuclease is a heterotrimeric enzyme. Rauhut R, et al. J Biol Chem, 1990 Oct 25. PMID 2211694
    3. Sen34p depletion blocks tRNA splicing in vivo and delays rRNA processing. Volta V, et al. Biochem Biophys Res Commun, 2005 Nov 11. PMID 16188229
    4. The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases. Trotta CR, et al. Cell, 1997 Jun 13. PMID 9200603
    5. The tRNA Splicing Endonuclease Complex Cleaves the Mitochondria-localized CBP1 mRNA. Tsuboi T, et al. J Biol Chem, 2015 Jun 26. PMID 25971974, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sen34p is absolutely required for tRNA splicing and may affect also rRNA maturation.
      Title: Sen34p depletion blocks tRNA splicing in vivo and delays rRNA processing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-intron endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-intron endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA-intron endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-intron endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA splicing, via endonucleolytic cleavage and ligation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA-type intron splice site recognition and cleavage IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA-type intron splice site recognition and cleavage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of tRNA-intron endonuclease complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of tRNA-intron endonuclease complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA splicing endonuclease subunit SEN34
    NP_009405.1
    • Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease (Sen complex) is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen complex also cleaves the CBP1 mRNA at the mitochondrial surface; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      158966..159793
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178212.1 → NP_009405.1  TPA: tRNA splicing endonuclease subunit SEN34 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009405.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPM0, P39707
      UniProtKB/TrEMBL
      A7A0H1, C7GTB6, G2W8N4
      Conserved Domains (1) summary
      TIGR00324
      Location:94 → 272
      endA; tRNA-intron lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39707.1

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