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    YKE4 Zn(2+) transporter YKE4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854789, updated on 29-Jun-2024

    Summary

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    Gene symbol
    YKE4
    Gene description
    Zn(2+) transporter YKE4
    Primary source
    FungiDB:YIL023C
    Locus tag
    YIL023C
    See related
    SGD:S000001285; AllianceGenome:SGD:S000001285; VEuPathDB:YIL023C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables zinc ion transmembrane transporter activity. Involved in zinc ion transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome and Ehlers-Danlos syndrome spondylodysplastic type 3. Orthologous to several human genes including SLC39A7 (solute carrier family 39 member 7). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YKE4 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (309386..310426, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Irr1p Neighboring gene uncharacterized protein Neighboring gene protein translocase subunit TIM44 Neighboring gene DNA-directed RNA polymerase II core subunit RPB3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MCHM Acts as a Hydrotrope, Altering the Balance of Metals in Yeast. Pupo A, et al. Biol Trace Elem Res, 2020 May. PMID 31392542, Free PMC Article
    2. TagSmart: analysis and visualization for yeast mutant fitness data measured by tag microarrays. Kim C, et al. BMC Bioinformatics, 2007 Apr 18. PMID 17442117, Free PMC Article
    3. YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae. Kumánovics A, et al. J Biol Chem, 2006 Aug 11. PMID 16760462
    4. The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. Churcher C, et al. Nature, 1997 May 29. PMID 9169870
    5. Exploring genetic suppression interactions on a global scale. van Leeuwen J, et al. Science, 2016 Nov 4. PMID 27811238, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yke4p balances zinc levels between the cytosol and the secretory pathway
      Title: YKE4 (YIL023C) encodes a bidirectional zinc transporter in the endoplasmic reticulum of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zn(2+) transporter YKE4
    NP_012241.1
    • Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      309386..310426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179373.1 → NP_012241.1  TPA: Zn(2+) transporter YKE4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012241.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVQ6, P40544
      UniProtKB/TrEMBL
      A0A8H4C1N8, G2WGC1, N1P277
      Conserved Domains (1) summary
      pfam02535
      Location:63 → 344
      Zip; ZIP Zinc transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40544.1

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