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    FSH1 putative serine hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856445, updated on 17-May-2024

    Summary

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    Gene symbol
    FSH1
    Gene description
    putative serine hydrolase
    Primary source
    FungiDB:YHR049W
    Locus tag
    YHR049W
    See related
    SGD:S000001091; AllianceGenome:SGD:S000001091; VEuPathDB:YHR049W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables lysophospholipase activity. Involved in apoptotic process. Located in cytoplasm and nucleus. Orthologous to human OVCA2 (OVCA2 serine hydrolase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FSH1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (206462..207193)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene arginine/alanine aminopeptidase Neighboring gene Yhk8p Neighboring gene divalent metal ion transporter SMF2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FSH1 overexpression triggers apoptosis in Saccharomyces cerevisiae. Gowsalya R, et al. Antonie Van Leeuwenhoek, 2019 Dec. PMID 31363875
    2. Crystal structure of yeast YHR049W/FSH1, a member of the serine hydrolase family. Quevillon-Cheruel S, et al. Protein Sci, 2005 May. PMID 15802654, Free PMC Article
    3. FSH1 encodes lysophospholipase activity in Saccharomyces cerevisiae. Ramachandran G, et al. Biotechnol Lett, 2021 Jan. PMID 32920715
    4. Comparative analysis of the human serine hydrolase OVCA2 to the model serine hydrolase homolog FSH1 from S. cerevisiae. Bun JS, et al. PLoS One, 2020. PMID 32182256, Free PMC Article
    5. FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae. Gowsalya R, et al. FEMS Yeast Res, 2019 May 1. PMID 30776074

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on ester bonds IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lysophospholipase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative serine hydrolase
    NP_011915.1
    • Lysophospholipase; hydrolyzes lysophosphatidylserine to release free fatty acid; involved in regulated cell death; localizes to both the nucleus and cytoplasm; contains a catalytic triad of Ser-His-Asp that is part of an alpha/beta hydrolase fold and a lipase motif (GXSXG); sequence similarity to Fsh2p and Fsh3p and the human candidate tumor suppressor and serine hydrolase, OVCA2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      206462..207193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179179.1 → NP_011915.1  TPA: putative serine hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011915.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKZ7, P38777
      UniProtKB/TrEMBL
      A0A6A5PX45, A6ZSV6, B3LSG8, B5VJY0, C7GT88, C8ZAC0, G2WFC2, N1P3B6
      Conserved Domains (1) summary
      pfam03959
      Location:6 → 229
      FSH1; Serine hydrolase (FSH1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38777.1

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