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    MSC7 meiotic recombination directing protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856434, updated on 28-Oct-2024

    Summary

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    Official Symbol
    MSC7
    Official Full Name
    meiotic recombination directing protein
    Primary source
    SGD:S000001081
    Locus tag
    YHR039C
    See related
    AllianceGenome:SGD:S000001081; FungiDB:YHR039C; VEuPathDB:YHR039C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable aldehyde dehydrogenase (NAD+) activity. Involved in reciprocal meiotic recombination. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See MSC7 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (184875..186809, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene 1-pyrroline-5-carboxylate dehydrogenase Neighboring gene Rrf1p Neighboring gene H(+)-transporting V1 sector ATPase subunit G Neighboring gene Bcd1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Thompson DA, et al. Genetics, 1999 Oct. PMID 10511544, Free PMC Article
    2. Ltc1 is an ER-localized sterol transporter and a component of ER-mitochondria and ER-vacuole contacts. Murley A, et al. J Cell Biol, 2015 May 25. PMID 25987606, Free PMC Article
    3. ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Manford AG, et al. Dev Cell, 2012 Dec 11. PMID 23237950
    4. Cross-compartment signal propagation in the mitotic exit network. Zhou X, et al. Elife, 2021 Jan 22. PMID 33481703, Free PMC Article
    5. Exo1 recruits Cdc5 polo kinase to MutLγ to ensure efficient meiotic crossover formation. Sanchez A, et al. Proc Natl Acad Sci U S A, 2020 Dec 1. PMID 33199619, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    meiotic recombination directing protein
    NP_011904.1
    • hypothetical protein; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      184875..186809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179169.1 → NP_011904.1  TPA: meiotic recombination directing protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011904.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKY6, P38694
      UniProtKB/TrEMBL
      A6ZSU5, B3LSF9, B5VJX1, C7GTU1, G2WFB1, N1P9M1
      Conserved Domains (1) summary
      cd07098
      Location:115 → 590
      ALDH_F15-22; Aldehyde dehydrogenase family 15A1 and 22A1-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38694.1

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