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    GIP2 Gip2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856781, updated on 28-Oct-2024

    Summary

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    Official Symbol
    GIP2
    Official Full Name
    Gip2p
    Primary source
    SGD:S000000856
    Locus tag
    YER054C
    See related
    AllianceGenome:SGD:S000000856; FungiDB:YER054C; VEuPathDB:YER054C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein phosphatase regulator activity. Involved in glycogen metabolic process. Part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to several human genes including PPP1R3A (protein phosphatase 1 regulatory subunit 3A); PPP1R3B (protein phosphatase 1 regulatory subunit 3B); and PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See GIP2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (262052..263698, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Cu/Pi carrier Neighboring gene uncharacterized protein Neighboring gene ATP phosphoribosyltransferase Neighboring gene purine-cytosine permease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Yeger-Lotem E, et al. Nat Genet, 2009 Mar. PMID 19234470, Free PMC Article
    2. Improvement in D-xylose utilization and isobutanol production in S. cerevisiae by adaptive laboratory evolution and rational engineering. Promdonkoy P, et al. J Ind Microbiol Biotechnol, 2020 Jul. PMID 32430798
    3. Yeast PIG genes: PIG1 encodes a putative type 1 phosphatase subunit that interacts with the yeast glycogen synthase Gsy2p. Cheng C, et al. Yeast, 1997 Jan. PMID 9046081
    4. Protein phosphatase type 1 regulates ion homeostasis in Saccharomyces cerevisiae. Williams-Hart T, et al. Genetics, 2002 Apr. PMID 11973298, Free PMC Article
    5. Epistatic buffering of fitness loss in yeast double deletion strains. Jasnos L, et al. Nat Genet, 2007 Apr. PMID 17322879

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycogen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of protein phosphatase type 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Gip2p
    NP_010974.1
    • Putative regulatory subunit of protein phosphatase Glc7p; involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p; GIP2 has a paralog, PIG2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      262052..263698 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178945.1 → NP_010974.1  TPA: Gip2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010974.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLV7, P40036
      UniProtKB/TrEMBL
      N1PA40
      Conserved Domains (1) summary
      pfam03370
      Location:429 → 534
      CBM_21; Carbohydrate/starch-binding module (family 21)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40036.1

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