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    PFU1 Pfu1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851900, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PFU1
    Official Full Name
    Pfu1p
    Primary source
    SGD:S000002714
    Locus tag
    YDR306C
    See related
    AllianceGenome:SGD:S000002714; FungiDB:YDR306C; VEuPathDB:YDR306C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PFU1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1073735..1075171, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase family protein CPR5 Neighboring gene bis(5'-adenosyl)-triphosphatase Neighboring gene tRNA-Val Neighboring gene putative dolichyl-phosphate-mannose--protein mannosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sgt1p contributes to cyclic AMP pathway activity and physically interacts with the adenylyl cyclase Cyr1p/Cdc35p in budding yeast. Dubacq C, et al. Eukaryot Cell, 2002 Aug. PMID 12456005, Free PMC Article
    2. Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway. Rangarajan N, et al. J Biol Chem, 2019 Oct 4. PMID 31399514, Free PMC Article
    3. SCF ubiquitin protein ligases and phosphorylation-dependent proteolysis. Willems AR, et al. Philos Trans R Soc Lond B Biol Sci, 1999 Sep 29. PMID 10582239, Free PMC Article
    4. A longevity protein, Lag2, interacts with SCF complex and regulates SCF function. Liu Y, et al. EMBO J, 2009 Nov 4. PMID 19763088, Free PMC Article
    5. Identification of F-box proteins that are involved in resistance to methylmercury in Saccharomyces cerevisiae. Hwang GW, et al. FEBS Lett, 2006 Dec 22. PMID 17141224

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SCF ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Pfu1p
    NP_010592.1
    • F-box protein that regulates pheromone-dependent morphogenesis; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1073735..1075171 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180614.1 → NP_010592.1  TPA: Pfu1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010592.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VST5, Q06640
      UniProtKB/TrEMBL
      A6ZYQ4, B3LFZ0, B5VGI5, C7GQV6, C8Z5L7
      Conserved Domains (1) summary
      pfam13306
      Location:275 → 379
      LRR_5; Leucine rich repeats (6 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06640.1

    Gene LinkOut

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