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    IFA38 ketoreductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852456, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IFA38
    Official Full Name
    ketoreductase
    Primary source
    SGD:S000000363
    Locus tag
    YBR159W
    See related
    AllianceGenome:SGD:S000000363; FungiDB:YBR159W; VEuPathDB:YBR159W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ketoreductase activity. Involved in fatty acid elongation; sphingolipid biosynthetic process; and very long-chain fatty acid biosynthetic process. Located in endoplasmic reticulum membrane. Used to study cancer; gynecomastia; polycystic kidney disease; and pseudohermaphroditism. Human ortholog(s) of this gene implicated in 17-beta hydroxysteroid dehydrogenase 3 deficiency; disorder of sexual development; and pseudohermaphroditism. Orthologous to several human genes including HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IFA38 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (558685..559728)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Ics2p Neighboring gene Amn1p Neighboring gene cyclin-dependent serine/threonine-protein kinase CDC28 Neighboring gene mannosylinositol phosphorylceramide synthase catalytic subunit CSH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid functional and evolutionary changes follow gene duplication in yeast. Naseeb S, et al. Proc Biol Sci, 2017 Aug 30. PMID 28835561, Free PMC Article
    2. Expression of 17beta-hydroxysteroid dehydrogenases in mesophilic and extremophilic yeast. Rizner TL, et al. Steroids, 2001 Jan. PMID 11090658
    3. Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation. Kihara A, et al. J Biol Chem, 2008 Apr 25. PMID 18272525
    4. Functional differentiation and selective inactivation of multiple Saccharomyces cerevisiae genes involved in very-long-chain fatty acid synthesis. Rössler H, et al. Mol Genet Genomics, 2003 May. PMID 12684876
    5. Sequence and functional analysis of a 7.2 kb DNA fragment containing four open reading frames located between RPB5 and CDC28 on the right arm of chromosome II. Rose M, et al. Yeast, 1995 Jul. PMID 7483850

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Although YBR159W localizes to the endoplasmic reticulum membrane, subcellular fractionation experiments show that a fraction of eIF2B cofractionates with lipid membranes in a YBR159W-independent manner.
      Title: The yeast eukaryotic translation initiation factor 2B translation initiation complex interacts with the fatty acid synthesis enzyme YBR159W and endoplasmic reticulum membranes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ketoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ketoreductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables very-long-chain 3-oxoacyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in very long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ketoreductase
    NP_009717.1
    • Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      558685..559728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178507.1 → NP_009717.1  TPA: ketoreductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009717.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZLA1, B3LN00, D6VQF4, P38286
      UniProtKB/TrEMBL
      B5VEB5, C7GUU5, D3UEQ3, G2W9G1, N1P8A9
      Conserved Domains (1) summary
      cd05356
      Location:62 → 310
      17beta-HSD1_like_SDR_c; 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38286.1

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