ALG1 chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ALG1
Gene description: chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase
Primary source: FungiDB:YBR110W
Locus tag: YBR110W
See related: SGD:S000000314; AllianceGenome:SGD:S000000314; VEuPathDB:YBR110W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables beta-1,4-mannosyltransferase activity. Involved in oligosaccharide-lipid intermediate biosynthetic process and protein N-linked glycosylation. Located in endoplasmic reticulum. Used to study congenital disorder of glycosylation; congenital disorder of glycosylation Ik; and congenital disorder of glycosylation type I. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ik. Orthologous to several human genes including ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ALG1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (458872..460221)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The roles of Alg2 and Alg1 in the dolichol pathway were studied.
Title: In vitro evidence for the dual function of Alg2 and Alg11: essential mannosyltransferases in N-linked glycoprotein biosynthesis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables beta-1,4-mannosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables chitobiosyldiphosphodolichol beta-mannosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables mannosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannosyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in oligosaccharide-lipid intermediate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein N-linked glycosylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IPI Inferred from Physical Interaction more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase

NP_009668.3

EC 2.4.1.142

Mannosyltransferase; involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability; human homolog ALG1 complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

458872..460221

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178458.3 → NP_009668.3 TPA: chitobiosyldiphosphodolichol beta-1,4 mannosyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009668.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQA9, P16661

UniProtKB/TrEMBL

A0A8H4F6L5, C7GUK8, G2W9B5, N1P6M7

Conserved Domains (1) summary

cd03816
Location:36 → 445

GT33_ALG1-like; chitobiosyldiphosphodolichol beta-mannosyltransferase and similar proteins