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    UBP16 putative ubiquitin-specific protease UBP16 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856032, updated on 9-Jun-2024

    Summary

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    Gene symbol
    UBP16
    Gene description
    putative ubiquitin-specific protease UBP16
    Primary source
    FungiDB:YPL072W
    Locus tag
    YPL072W
    See related
    SGD:S000005993; AllianceGenome:SGD:S000005993; VEuPathDB:YPL072W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable thiol-dependent deubiquitinase. Predicted to be involved in protein deubiquitination. Located in mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UBP16 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (418512..420011)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene transcription regulator GCR1 Neighboring gene putative AAA family ATPase YTA6 Neighboring gene uncharacterized protein Neighboring gene guanine nucleotide exchange factor MUK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast deubiquitinating enzyme Ubp16 is anchored to the outer mitochondrial membrane. Kinner A, et al. FEBS Lett, 2003 Aug 14. PMID 12914939
    2. Ubiquitin-dependent protein degradation. Hochstrasser M. Annu Rev Genet, 1996. PMID 8982460
    3. Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae. Amerik AY, et al. Biol Chem, 2000 Sep-Oct. PMID 11076031
    4. Genetic interactions of a putative Arabidopsis thaliana ubiquitin-ligase with components of the Saccharomyces cerevisiae ubiquitination machinery. Aguilar-Henonin L, et al. Curr Genet, 2006 Oct. PMID 16897085
    5. Identification of deubiquitinating enzymes involved in methylmercury toxicity in Saccharomyces cerevisiae. Hwang GW, et al. J Toxicol Sci, 2012. PMID 23208446

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane HDA PubMed 
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    putative ubiquitin-specific protease UBP16
    NP_015253.1
    • Putative deubiquitinating enzyme anchored to the outer mitochondrial membrane; probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      418512..420011
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183886.1 → NP_015253.1  TPA: putative ubiquitin-specific protease UBP16 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015253.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3U3, Q02863
      UniProtKB/TrEMBL
      A0A8H4F6S9, A6ZWH7, B3LKZ7, B5VT91, C7GTY5, N1P1P1
      Conserved Domains (1) summary
      cd02662
      Location:54 → 495
      Peptidase_C19F; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02863.1

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