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    MSB4 Rab GTPase-activating protein MSB4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854037, updated on 17-May-2024

    Summary

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    Gene symbol
    MSB4
    Gene description
    Rab GTPase-activating protein MSB4
    Primary source
    FungiDB:YOL112W
    Locus tag
    YOL112W
    See related
    SGD:S000005472; AllianceGenome:SGD:S000005472; VEuPathDB:YOL112W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables GTPase activator activity. Involved in exocytosis and formin-nucleated actin cable assembly. Located in cellular bud tip. Part of incipient cellular bud site and polarisome. Used to study Ewing sarcoma. Orthologous to several human genes including GRTP1 (growth hormone regulated TBC protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MSB4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (106710..108188)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Pth4p Neighboring gene putative serine/threonine protein kinase SKM1 Neighboring gene Mdy2p Neighboring gene Shr5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Co-deletion of the MSB3 and MSB4 coding regions affects bipolar budding and perturbs the organization of the actin cytoskeleton. Bach S, et al. Yeast, 2000 Aug. PMID 10923023
    2. At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity. Bizimungu C, et al. Biochem Biophys Res Commun, 2005 Sep 30. PMID 16099424
    3. Myosin-V is activated by binding secretory cargo and released in coordination with Rab/exocyst function. Donovan KW, et al. Dev Cell, 2012 Oct 16. PMID 23079598, Free PMC Article
    4. Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene. Bizimungu C, et al. Biochem Biophys Res Commun, 2003 Oct 17. PMID 14521938
    5. Disruption and functional analysis of six ORFs on chromosome XV: YOL117w, YOL115w ( TRF4), YOL114c, YOL112w ( MSB4), YOL111c and YOL072w. Iwanejko L, et al. Yeast, 1999 Oct. PMID 10514570

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Msb3 and Msb4 interact with Cdc42 and polarisome components to regulate cell polarity
      Title: Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in formin-nucleated actin cable assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in formin-nucleated actin cable assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cellular bud IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud neck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cellular bud tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in incipient cellular bud site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of polarisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rab GTPase-activating protein MSB4
    NP_014529.1
    • GTPase-activating protein of the Ras superfamily; acts primarily on Sec4p, localizes to the bud site and bud tip; msb3 msb4 double mutation causes defects in secretion and actin organization; similar to the TBC-domain Tre2 oncogene; MSB4 has a paralog, MSB3, that arose from the whole genome duplication; human homolog USP6NL can complement yeast msb3 msb4 double null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      106710..108188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183366.1 → NP_014529.1  TPA: Rab GTPase-activating protein MSB4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014529.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1V5, Q05377, Q05378, Q12317
      UniProtKB/TrEMBL
      A0A8H4BWJ5, A6ZN98, C7GSS4, G2WMC4
      Conserved Domains (1) summary
      COG5210
      Location:53 → 461
      COG5210; GTPase-activating protein [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12317.1

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