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    YNG2 histone acetyltransferase YNG2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856490, updated on 28-Oct-2024

    Summary

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    Official Symbol
    YNG2
    Official Full Name
    histone acetyltransferase YNG2
    Primary source
    SGD:S000001132
    Locus tag
    YHR090C
    See related
    AllianceGenome:SGD:S000001132; FungiDB:YHR090C; VEuPathDB:YHR090C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    EAF4; NBN1
    Summary
    Enables methylated histone binding activity. Contributes to histone acetyltransferase activity. Involved in DNA repair. Located in cytosol and nucleus. Part of NuA4 histone acetyltransferase complex and piccolo histone acetyltransferase complex. Used to study hepatocellular carcinoma; melanoma; and squamous cell carcinoma. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ING3 (inhibitor of growth family member 3); ING4 (inhibitor of growth family member 4); and ING5 (inhibitor of growth family member 5). [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See YNG2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (283777..284625, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene rRNA-binding ribosome biosynthesis protein RPF1 Neighboring gene H/ACA snoRNP pseudouridylase subunit GAR1 Neighboring gene arginine--tRNA ligase MSR1 Neighboring gene hexose transporter HXT4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yng2p-dependent NuA4 histone H4 acetylation activity is required for mitotic and meiotic progression. Choy JS, et al. J Biol Chem, 2001 Nov 23. PMID 11544250
    2. The Saccharomyces cerevisiae Piccolo NuA4 histone acetyltransferase complex requires the Enhancer of Polycomb A domain and chromodomain to acetylate nucleosomes. Selleck W, et al. Mol Cell Biol, 2005 Jul. PMID 15964809, Free PMC Article
    3. Nucleosome recognition by the Piccolo NuA4 histone acetyltransferase complex. Berndsen CE, et al. Biochemistry, 2007 Feb 27. PMID 17274630, Free PMC Article
    4. Interspecies data mining to predict novel ING-protein interactions in human. Gordon PM, et al. BMC Genomics, 2008 Sep 18. PMID 18801192, Free PMC Article
    5. Histone hypoacetylation-activated genes are repressed by acetyl-CoA- and chromatin-mediated mechanism. Mehrotra S, et al. Biochim Biophys Acta, 2014 Sep. PMID 24907648, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of piccolo histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone acetyltransferase YNG2
    NP_011958.1
    • Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; relocalizes to the cytosol in response to hypoxia; similar to human tumor suppressor ING1 and its isoforms ING4 and ING5

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      283777..284625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179220.1 → NP_011958.1  TPA: histone acetyltransferase YNG2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011958.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL42, P38806
      UniProtKB/TrEMBL
      A6ZT00, B3LSK8, C7GWV4, C8Z9N5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38806.1

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