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    SNT309 Snt309p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856216, updated on 29-Jun-2024

    Summary

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    Gene symbol
    SNT309
    Gene description
    Snt309p
    Primary source
    FungiDB:YPR101W
    Locus tag
    YPR101W
    See related
    SGD:S000006305; AllianceGenome:SGD:S000006305; VEuPathDB:YPR101W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NTC25
    Summary
    Predicted to contribute to first spliceosomal transesterification activity. Involved in mRNA splicing, via spliceosome. Part of Prp19 complex and U2-type catalytic step 1 spliceosome. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SNT309 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (730492..731019)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Tmh18p Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein MRPL51 Neighboring gene ribosomal 60S subunit protein L11A Neighboring gene proteasome core particle subunit beta 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Snt309p, a component of the Prp19p-associated complex that interacts with Prp19p and associates with the spliceosome simultaneously with or immediately after dissociation of U4 in the same manner as Prp19p. Chen HR, et al. Mol Cell Biol, 1998 Apr. PMID 9528791, Free PMC Article
    2. Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing. Chen HR, et al. Proc Natl Acad Sci U S A, 1999 May 11. PMID 10318896, Free PMC Article
    3. Identification and characterization of two novel components of the Prp19p-associated complex, Ntc30p and Ntc20p. Chen CH, et al. J Biol Chem, 2001 Jan 5. PMID 11018040
    4. Thermoconditional modulation of the pleiotropic sensitivity phenotype by the Saccharomyces cerevisiae PRP19 mutant allele pso4-1. Revers LF, et al. Nucleic Acids Res, 2002 Nov 15. PMID 12434004, Free PMC Article
    5. Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling. Chen CH, et al. RNA, 2006 May. PMID 16540691, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to first spliceosomal transesterification activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type catalytic step 1 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Snt309p
    NP_015426.1
    • Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      730492..731019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184198.1 → NP_015426.1  TPA: Snt309p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015426.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W499, Q06091
      UniProtKB/TrEMBL
      A0A8H4F8B3, A6ZWY1, B3LK65, B5VTP2, C8ZJC3, G2WPR7, N1NW37
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06091.1

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