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    BIRC6 baculoviral IAP repeat containing 6 [ Homo sapiens (human) ]

    Gene ID: 57448, updated on 28-Oct-2024

    Summary

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    Official Symbol
    BIRC6provided by HGNC
    Official Full Name
    baculoviral IAP repeat containing 6provided by HGNC
    Primary source
    HGNC:HGNC:13516
    See related
    Ensembl:ENSG00000115760 MIM:605638; AllianceGenome:HGNC:13516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BRUCE; APOLLON
    Summary
    This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 6.5), ovary (RPKM 6.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BIRC6 in Genome Data Viewer
    Location:
    2p22.3
    Exon count:
    75
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (32357023..32618878)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (32405536..32667526)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (32582091..32843945)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:32502088-32502833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11340 Neighboring gene NLR family CARD domain containing 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:32518022-32518694 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:32521211-32521404 Neighboring gene Yip1 domain family member 4 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:32581762-32582274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11342 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:32582789-32583301 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:32586084-32586282 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:32662063-32662288 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:32672333-32672910 Neighboring gene microRNA 558 Neighboring gene BIRC6 antisense RNA 2 Neighboring gene uncharacterized LOC124905985 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:32852317-32852978 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:32852979-32853638 Neighboring gene microRNA 4765 Neighboring gene tetratricopeptide repeat domain 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of BIRC6 Is a Predictor of Prognosis for Colorectal Cancer. Hu T, et al. PLoS One, 2015. PMID 25933218, Free PMC Article
    2. [Knock-down of apollon gene by antisense oligodeoxynucleotide inhibits the proliferation of Lovo cells and enhances chemo-sensitivity]. He JH, et al. Yao Xue Xue Bao, 2011 Feb. PMID 21542283
    3. Comparative proteomics of colon cancer stem cells and differentiated tumor cells identifies BIRC6 as a potential therapeutic target. Van Houdt WJ, et al. Mol Cell Proteomics, 2011 Dec. PMID 21788403, Free PMC Article
    4. [Small interfering RNA targeting Apollon enhances the chemosensitivity of hepatocellular carcinoma cells in vitro]. Chen JF, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2011 Oct. PMID 22027771
    5. BIRC6/Apollon gene expression in childhood acute leukemia: impact on therapeutic response and prognosis. Ismail EA, et al. Eur J Haematol, 2012 Feb. PMID 22085301

    See all (139) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer.
      Title: CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer.
    2. Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
      Title: Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
    3. Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
      Title: Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
    4. Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.
      Title: Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.
    5. Exploring the Role of the Inhibitor of Apoptosis BIRC6 in Breast Cancer: A Database Analysis.
      Title: Exploring the Role of the Inhibitor of Apoptosis BIRC6 in Breast Cancer: A Database Analysis.
    6. Oral Squamous Cell Carcinoma: The Role of BIRC6 Serum Level.
      Title: Oral Squamous Cell Carcinoma: The Role of BIRC6 Serum Level.
    7. BIRC6 modifies risk of invasive bacterial infection in Kenyan children.
      Title: BIRC6 modifies risk of invasive bacterial infection in Kenyan children.
    8. Silencing circBIRC6 inhibits the proliferation, invasion, migration and epithelialmesenchymal transition of bladder cancer cells by targeting the miR4953p/XBP1 signaling axis.
      Title: Silencing circ‑BIRC6 inhibits the proliferation, invasion, migration and epithelial‑mesenchymal transition of bladder cancer cells by targeting the miR‑495‑3p/XBP1 signaling axis.
    9. BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque.
      Title: BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque.
    10. MALAT1 knockdown inhibits prostate cancer progression by regulating miR-140/BIRC6 axis.
      Title: MALAT1 knockdown inhibits prostate cancer progression by regulating miR-140/BIRC6 axis.
    Submit: New GeneRIF Correction See all GeneRIFs (46)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13726, FLJ13786, KIAA1289, AL133243.1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in labyrinthine layer development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    baculoviral IAP repeat-containing protein 6
    Names
    BIR repeat-containing ubiquitin-conjugating enzyme
    RING-type E3 ubiquitin transferase BIRC6
    ubiquitin-conjugating BIR-domain enzyme apollon
    NP_001365054.1
    NP_057336.3
    XP_005264507.2
    XP_005264508.2
    XP_005264509.2
    XP_005264510.2
    XP_005264512.2
    XP_006712117.1
    XP_006712118.1
    XP_006712119.1
    XP_011531305.1
    XP_016860045.1
    XP_016860046.1
    XP_016860047.1
    XP_047301114.1
    XP_047301115.1
    XP_047301116.1
    XP_047301117.1
    XP_047301118.1
    XP_047301119.1
    XP_047301120.1
    XP_047301121.1
    XP_047301122.1
    XP_047301123.1
    XP_047301124.1
    XP_047301125.1
    XP_047301126.1
    XP_047301127.1
    XP_047301128.1
    XP_047301129.1
    XP_047301130.1
    XP_047301131.1
    XP_047301132.1
    XP_047301133.1
    XP_047301134.1
    XP_047301135.1
    XP_047301136.1
    XP_047301137.1
    XP_047301138.1
    XP_047301139.1
    XP_047301140.1
    XP_047301141.1
    XP_047301142.1
    XP_047301143.1
    XP_047301144.1
    XP_047301145.1
    XP_047301146.1
    XP_047301147.1
    XP_047301148.1
    XP_047301149.1
    XP_054199104.1
    XP_054199105.1
    XP_054199106.1
    XP_054199107.1
    XP_054199108.1
    XP_054199109.1
    XP_054199110.1
    XP_054199111.1
    XP_054199112.1
    XP_054199113.1
    XP_054199114.1
    XP_054199115.1
    XP_054199116.1
    XP_054199117.1
    XP_054199118.1
    XP_054199119.1
    XP_054199120.1
    XP_054199121.1
    XP_054199122.1
    XP_054199123.1
    XP_054199124.1
    XP_054199125.1
    XP_054199126.1
    XP_054199127.1
    XP_054199128.1
    XP_054199129.1
    XP_054199130.1
    XP_054199131.1
    XP_054199132.1
    XP_054199133.1
    XP_054199134.1
    XP_054199135.1
    XP_054199136.1
    XP_054199137.1
    XP_054199138.1
    XP_054199139.1
    XP_054199140.1
    XP_054199141.1
    XP_054199142.1
    XP_054199143.1
    XP_054199144.1
    XP_054199145.1
    XP_054199146.1
    XP_054199147.1
    XP_054199148.1
    XP_054199149.1
    XP_054199150.1
    XP_054199151.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001378125.1 → NP_001365054.1  baculoviral IAP repeat-containing protein 6 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AL133243, AL133245, AL133246, KF456651, KF456657
      Conserved Domains (3) summary
      cd00022
      Location:259 → 332
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4596 → 4734
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3462 → 3617
      BIRC6; Baculoviral IAP repeat-containing protein 6

    2. NM_016252.4 → NP_057336.3  baculoviral IAP repeat-containing protein 6 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL133243, AL133245, AL133246, KF456651, KF456657
      Consensus CDS
      CCDS33175.2
      UniProtKB/Swiss-Prot
      Q9NR09, Q9ULD1
      Related
      ENSP00000393596.2, ENST00000421745.7
      Conserved Domains (3) summary
      cd00022
      Location:287 → 360
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4597 → 4735
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3466 → 3618
      DUF3643; Protein of unknown function (DUF3643)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      32357023..32618878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006712055.4 → XP_006712118.1  baculoviral IAP repeat-containing protein 6 isoform X11

      Conserved Domains (3) summary
      cd00022
      Location:287 → 360
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4604 → 4742
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3473 → 3625
      DUF3643; Protein of unknown function (DUF3643)

    2. XM_005264451.5 → XP_005264508.2  baculoviral IAP repeat-containing protein 6 isoform X3

      Conserved Domains (3) summary
      cd00022
      Location:287 → 360
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4615 → 4753
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3484 → 3636
      DUF3643; Protein of unknown function (DUF3643)

    3. XM_047445167.1 → XP_047301123.1  baculoviral IAP repeat-containing protein 6 isoform X17

    4. XM_006712054.4 → XP_006712117.1  baculoviral IAP repeat-containing protein 6 isoform X2

      Conserved Domains (3) summary
      cd00022
      Location:287 → 360
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4618 → 4756
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3487 → 3639
      DUF3643; Protein of unknown function (DUF3643)

    5. XM_017004556.2 → XP_016860045.1  baculoviral IAP repeat-containing protein 6 isoform X15

    6. XM_047445160.1 → XP_047301116.1  baculoviral IAP repeat-containing protein 6 isoform X7

    7. XM_006712056.4 → XP_006712119.1  baculoviral IAP repeat-containing protein 6 isoform X18

      Conserved Domains (3) summary
      cd00022
      Location:287 → 360
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4591 → 4729
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3460 → 3612
      DUF3643; Protein of unknown function (DUF3643)

    8. XM_047445170.1 → XP_047301126.1  baculoviral IAP repeat-containing protein 6 isoform X22

    9. XM_047445174.1 → XP_047301130.1  baculoviral IAP repeat-containing protein 6 isoform X28

    10. XM_005264450.5 → XP_005264507.2  baculoviral IAP repeat-containing protein 6 isoform X1

      Conserved Domains (3) summary
      cd00022
      Location:287 → 360
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4620 → 4758
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3489 → 3641
      DUF3643; Protein of unknown function (DUF3643)

    11. XM_047445165.1 → XP_047301121.1  baculoviral IAP repeat-containing protein 6 isoform X14

    12. XM_047445159.1 → XP_047301115.1  baculoviral IAP repeat-containing protein 6 isoform X5

    13. XM_047445158.1 → XP_047301114.1  baculoviral IAP repeat-containing protein 6 isoform X4

    14. XM_047445162.1 → XP_047301118.1  baculoviral IAP repeat-containing protein 6 isoform X9

    15. XM_017004557.2 → XP_016860046.1  baculoviral IAP repeat-containing protein 6 isoform X20

    16. XM_047445172.1 → XP_047301128.1  baculoviral IAP repeat-containing protein 6 isoform X25

    17. XM_047445171.1 → XP_047301127.1  baculoviral IAP repeat-containing protein 6 isoform X23

    18. XM_047445177.1 → XP_047301133.1  baculoviral IAP repeat-containing protein 6 isoform X31

    19. XM_005264452.5 → XP_005264509.2  baculoviral IAP repeat-containing protein 6 isoform X6

      Conserved Domains (3) summary
      cd00022
      Location:287 → 360
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4610 → 4748
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3479 → 3631
      DUF3643; Protein of unknown function (DUF3643)

    20. XM_005264453.5 → XP_005264510.2  baculoviral IAP repeat-containing protein 6 isoform X12

      Conserved Domains (3) summary
      cd00022
      Location:287 → 360
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4601 → 4739
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3470 → 3622
      DUF3643; Protein of unknown function (DUF3643)

    21. XM_047445163.1 → XP_047301119.1  baculoviral IAP repeat-containing protein 6 isoform X10

    22. XM_047445166.1 → XP_047301122.1  baculoviral IAP repeat-containing protein 6 isoform X16

    23. XM_017004558.2 → XP_016860047.1  baculoviral IAP repeat-containing protein 6 isoform X26

      UniProtKB/TrEMBL
      A0A8V8TR92
      Related
      ENSP00000515026.1, ENST00000700519.1

    24. XM_047445180.1 → XP_047301136.1  baculoviral IAP repeat-containing protein 6 isoform X34

    25. XM_047445184.1 → XP_047301140.1  baculoviral IAP repeat-containing protein 6 isoform X38

    26. XM_047445161.1 → XP_047301117.1  baculoviral IAP repeat-containing protein 6 isoform X8

    27. XM_047445169.1 → XP_047301125.1  baculoviral IAP repeat-containing protein 6 isoform X21

    28. XM_047445164.1 → XP_047301120.1  baculoviral IAP repeat-containing protein 6 isoform X13

    29. XM_047445168.1 → XP_047301124.1  baculoviral IAP repeat-containing protein 6 isoform X19

    30. XM_047445176.1 → XP_047301132.1  baculoviral IAP repeat-containing protein 6 isoform X30

    31. XM_047445183.1 → XP_047301139.1  baculoviral IAP repeat-containing protein 6 isoform X37

    32. XM_047445182.1 → XP_047301138.1  baculoviral IAP repeat-containing protein 6 isoform X36

    33. XM_005264455.5 → XP_005264512.2  baculoviral IAP repeat-containing protein 6 isoform X24

      UniProtKB/TrEMBL
      A0A8V8TQB4
      Related
      ENSP00000515025.1, ENST00000700518.1
      Conserved Domains (3) summary
      cd00022
      Location:287 → 360
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4580 → 4718
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3449 → 3601
      DUF3643; Protein of unknown function (DUF3643)

    34. XM_047445178.1 → XP_047301134.1  baculoviral IAP repeat-containing protein 6 isoform X32

    35. XM_047445175.1 → XP_047301131.1  baculoviral IAP repeat-containing protein 6 isoform X29

    36. XM_047445186.1 → XP_047301142.1  baculoviral IAP repeat-containing protein 6 isoform X40

    37. XM_047445189.1 → XP_047301145.1  baculoviral IAP repeat-containing protein 6 isoform X43

    38. XM_047445188.1 → XP_047301144.1  baculoviral IAP repeat-containing protein 6 isoform X42

    39. XM_047445173.1 → XP_047301129.1  baculoviral IAP repeat-containing protein 6 isoform X27

    40. XM_047445181.1 → XP_047301137.1  baculoviral IAP repeat-containing protein 6 isoform X35

    41. XM_047445179.1 → XP_047301135.1  baculoviral IAP repeat-containing protein 6 isoform X33

    42. XM_047445185.1 → XP_047301141.1  baculoviral IAP repeat-containing protein 6 isoform X39

    43. XM_047445187.1 → XP_047301143.1  baculoviral IAP repeat-containing protein 6 isoform X41

    44. XM_047445191.1 → XP_047301147.1  baculoviral IAP repeat-containing protein 6 isoform X45

    45. XM_047445190.1 → XP_047301146.1  baculoviral IAP repeat-containing protein 6 isoform X44

    46. XM_011533003.3 → XP_011531305.1  baculoviral IAP repeat-containing protein 6 isoform X46

      Conserved Domains (3) summary
      cd00022
      Location:182 → 255
      BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
      cd00195
      Location:4519 → 4657
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
      pfam12356
      Location:3388 → 3540
      DUF3643; Protein of unknown function (DUF3643)

    47. XM_047445193.1 → XP_047301149.1  baculoviral IAP repeat-containing protein 6 isoform X48

    48. XM_047445192.1 → XP_047301148.1  baculoviral IAP repeat-containing protein 6 isoform X47

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      32405536..32667526
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054343139.1 → XP_054199114.1  baculoviral IAP repeat-containing protein 6 isoform X11

    2. XM_054343131.1 → XP_054199106.1  baculoviral IAP repeat-containing protein 6 isoform X3

    3. XM_054343145.1 → XP_054199120.1  baculoviral IAP repeat-containing protein 6 isoform X17

    4. XM_054343130.1 → XP_054199105.1  baculoviral IAP repeat-containing protein 6 isoform X2

    5. XM_054343143.1 → XP_054199118.1  baculoviral IAP repeat-containing protein 6 isoform X15

    6. XM_054343135.1 → XP_054199110.1  baculoviral IAP repeat-containing protein 6 isoform X7

    7. XM_054343146.1 → XP_054199121.1  baculoviral IAP repeat-containing protein 6 isoform X18

    8. XM_054343150.1 → XP_054199125.1  baculoviral IAP repeat-containing protein 6 isoform X22

    9. XM_054343156.1 → XP_054199131.1  baculoviral IAP repeat-containing protein 6 isoform X28

    10. XM_054343129.1 → XP_054199104.1  baculoviral IAP repeat-containing protein 6 isoform X1

    11. XM_054343142.1 → XP_054199117.1  baculoviral IAP repeat-containing protein 6 isoform X14

    12. XM_054343133.1 → XP_054199108.1  baculoviral IAP repeat-containing protein 6 isoform X5

    13. XM_054343132.1 → XP_054199107.1  baculoviral IAP repeat-containing protein 6 isoform X4

    14. XM_054343137.1 → XP_054199112.1  baculoviral IAP repeat-containing protein 6 isoform X9

    15. XM_054343148.1 → XP_054199123.1  baculoviral IAP repeat-containing protein 6 isoform X20

    16. XM_054343153.1 → XP_054199128.1  baculoviral IAP repeat-containing protein 6 isoform X25

    17. XM_054343151.1 → XP_054199126.1  baculoviral IAP repeat-containing protein 6 isoform X23

    18. XM_054343159.1 → XP_054199134.1  baculoviral IAP repeat-containing protein 6 isoform X31

    19. XM_054343134.1 → XP_054199109.1  baculoviral IAP repeat-containing protein 6 isoform X6

    20. XM_054343140.1 → XP_054199115.1  baculoviral IAP repeat-containing protein 6 isoform X12

    21. XM_054343138.1 → XP_054199113.1  baculoviral IAP repeat-containing protein 6 isoform X10

    22. XM_054343144.1 → XP_054199119.1  baculoviral IAP repeat-containing protein 6 isoform X16

    23. XM_054343154.1 → XP_054199129.1  baculoviral IAP repeat-containing protein 6 isoform X26

      UniProtKB/TrEMBL
      A0A8V8TR92

    24. XM_054343162.1 → XP_054199137.1  baculoviral IAP repeat-containing protein 6 isoform X34

    25. XM_054343166.1 → XP_054199141.1  baculoviral IAP repeat-containing protein 6 isoform X38

    26. XM_054343136.1 → XP_054199111.1  baculoviral IAP repeat-containing protein 6 isoform X8

    27. XM_054343149.1 → XP_054199124.1  baculoviral IAP repeat-containing protein 6 isoform X21

    28. XM_054343141.1 → XP_054199116.1  baculoviral IAP repeat-containing protein 6 isoform X13

    29. XM_054343147.1 → XP_054199122.1  baculoviral IAP repeat-containing protein 6 isoform X19

    30. XM_054343158.1 → XP_054199133.1  baculoviral IAP repeat-containing protein 6 isoform X30

    31. XM_054343165.1 → XP_054199140.1  baculoviral IAP repeat-containing protein 6 isoform X37

    32. XM_054343164.1 → XP_054199139.1  baculoviral IAP repeat-containing protein 6 isoform X36

    33. XM_054343152.1 → XP_054199127.1  baculoviral IAP repeat-containing protein 6 isoform X24

      UniProtKB/TrEMBL
      A0A8V8TQB4

    34. XM_054343160.1 → XP_054199135.1  baculoviral IAP repeat-containing protein 6 isoform X32

    35. XM_054343157.1 → XP_054199132.1  baculoviral IAP repeat-containing protein 6 isoform X29

    36. XM_054343168.1 → XP_054199143.1  baculoviral IAP repeat-containing protein 6 isoform X40

    37. XM_054343171.1 → XP_054199146.1  baculoviral IAP repeat-containing protein 6 isoform X43

    38. XM_054343170.1 → XP_054199145.1  baculoviral IAP repeat-containing protein 6 isoform X42

    39. XM_054343155.1 → XP_054199130.1  baculoviral IAP repeat-containing protein 6 isoform X27

    40. XM_054343163.1 → XP_054199138.1  baculoviral IAP repeat-containing protein 6 isoform X35

    41. XM_054343161.1 → XP_054199136.1  baculoviral IAP repeat-containing protein 6 isoform X33

    42. XM_054343167.1 → XP_054199142.1  baculoviral IAP repeat-containing protein 6 isoform X39

    43. XM_054343169.1 → XP_054199144.1  baculoviral IAP repeat-containing protein 6 isoform X41

    44. XM_054343173.1 → XP_054199148.1  baculoviral IAP repeat-containing protein 6 isoform X45

    45. XM_054343172.1 → XP_054199147.1  baculoviral IAP repeat-containing protein 6 isoform X44

    46. XM_054343174.1 → XP_054199149.1  baculoviral IAP repeat-containing protein 6 isoform X46

    47. XM_054343176.1 → XP_054199151.1  baculoviral IAP repeat-containing protein 6 isoform X48

    48. XM_054343175.1 → XP_054199150.1  baculoviral IAP repeat-containing protein 6 isoform X47

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NR09.3 GenPept UniProtKB/Swiss-Prot:Q9NR09

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