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    VP2 vacuolar H+-pyrophosphatase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844231, updated on 15-Feb-2024

    Summary

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    Gene symbol
    VP2
    Gene description
    vacuolar H+-pyrophosphatase 2
    Primary source
    Araport:AT1G78920
    Locus tag
    AT1G78920
    See related
    TAIR:AT1G78920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtVHP2;1; AVP2; AVPL1; F9K20.2; F9K20_2; vacuolar H+-pyrophosphatase 2; VACUOLAR-PYROPHOSPHATASE LIKE PROTEIN 1; VACUOLAR-TYPE H+-TRANSLOCATING INORGANIC PYROPHOSPHATASE; VHP2;1
    Summary
    Encodes a type II H+-PPases that localizes to and function as a proton pump of the Golgi apparatus in most tissues except for mature leaves.
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    Genomic context

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    See VP2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    17
    Sequence:
    Chromosome: 1; NC_003070.9 (29671413..29677537)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Pseudouridine synthase family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene kinase with adenine nucleotide alpha hydrolases-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel type Arabidopsis thaliana H(+)-PPase is localized to the Golgi apparatus. Mitsuda N, et al. FEBS Lett, 2001 Jan 12. PMID 11163790
    2. AVP2, a sequence-divergent, K(+)-insensitive H(+)-translocating inorganic pyrophosphatase from Arabidopsis. Drozdowicz YM, et al. Plant Physiol, 2000 May. PMID 10806252, Free PMC Article
    3. Quantification, organ-specific accumulation and intracellular localization of type II H(+)-pyrophosphatase in Arabidopsis thaliana. Segami S, et al. Plant Cell Physiol, 2010 Aug. PMID 20605924
    4. Label-free protein quantification for plant Golgi protein localization and abundance. Nikolovski N, et al. Plant Physiol, 2014 Oct. PMID 25122472, Free PMC Article
    5. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The type II H(+)-PPase functions as a proton pump in the Golgi and related vesicles in young tissues [VHP2;1]
      Title: Quantification, organ-specific accumulation and intracellular localization of type II H(+)-pyrophosphatase in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001124147.1
    NM_001334854.1
    NM_106541.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables diphosphate hydrolysis-driven proton transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diphosphate hydrolysis-driven proton transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables inorganic diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    colocalizes_with Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cis cisterna HDA PubMed 
    located_in endosome HDA PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in trans-Golgi network HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    vacuolar H+-pyrophosphatase 2
    NP_001117619.1
    • vacuolar H+-pyrophosphatase 2 (VP2); FUNCTIONS IN: hydrogen-translocating pyrophosphatase activity; INVOLVED IN: proton transport; LOCATED IN: Golgi apparatus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inorganic H+ pyrophosphatase (InterPro:IPR004131); BEST Arabidopsis thaliana protein match is: Inorganic H pyrophosphatase family protein (TAIR:AT1G16780.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_565195.1
    • vacuolar H+-pyrophosphatase 2 (VP2); FUNCTIONS IN: hydrogen-translocating pyrophosphatase activity; INVOLVED IN: proton transport; LOCATED IN: Golgi apparatus, vacuole; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inorganic H+ pyrophosphatase (InterPro:IPR004131); BEST Arabidopsis thaliana protein match is: Inorganic H pyrophosphatase family protein (TAIR:AT1G16780.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29671413..29677537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106541.4 → NP_565195.1  vacuolar H+-pyrophosphatase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565195.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56ZN6, Q9LDJ4, Q9MB70, Q9ZVB1
      UniProtKB/TrEMBL
      A0A178WC99, A0A5S9WVL1
      Conserved Domains (1) summary
      PLN02277
      Location:73 → 802
      PLN02277; H(+) -translocating inorganic pyrophosphatase

    2. NM_001124147.1 → NP_001117619.1  vacuolar H+-pyrophosphatase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001117619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56ZN6, Q9LDJ4, Q9MB70, Q9ZVB1
      UniProtKB/TrEMBL
      A0A178WC99, A0A5S9WVL1
      Conserved Domains (1) summary
      PLN02277
      Location:73 → 802
      PLN02277; H(+) -translocating inorganic pyrophosphatase

    3. NM_001334854.1 → NP_001322698.1  vacuolar H+-pyrophosphatase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56ZN6, Q9LDJ4, Q9MB70, Q9ZVB1
      UniProtKB/TrEMBL
      A0A178WC99, A0A5S9WVL1
      Conserved Domains (1) summary
      PLN02277
      Location:73 → 802
      PLN02277; H(+) -translocating inorganic pyrophosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q56ZN6.2

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