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    HMRA1 Hmra1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850459, updated on 2-Nov-2024

    Summary

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    Official Symbol
    HMRA1
    Official Full Name
    Hmra1p
    Primary source
    SGD:S000000694
    Locus tag
    YCR097W
    See related
    AllianceGenome:SGD:S000000694; FungiDB:YCR097W; VEuPathDB:YCR097W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YCR097WB
    Summary
    Enables transcription corepressor activity. Involved in regulation of mating-type specific transcription, DNA-templated. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See HMRA1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_001135.5 (293835..294321)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene homeodomain mating type protein a2 Neighboring gene tRNA-Thr Neighboring gene Git1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A synthetic silencer mediates SIR-dependent functions in Saccharomyces cerevisiae. McNally FJ, et al. Mol Cell Biol, 1991 Nov. PMID 1922068, Free PMC Article
    2. Engineered improvements in DNA-binding function of the MATa1 homeodomain reveal structural changes involved in combinatorial control. Hart B, et al. J Mol Biol, 2002 Feb 15. PMID 11851335
    3. Role of intron splicing in the function of the MATa1 gene of Saccharomyces cerevisiae. Ner SS, et al. Mol Cell Biol, 1989 Nov. PMID 2574822, Free PMC Article
    4. Splicing and spliceosome formation of the yeast MATa1 transcript require a minimum distance from the 5' splice site to the internal branch acceptor site. Köhrer K, et al. Nucleic Acids Res, 1988 Oct 25. PMID 3054807, Free PMC Article
    5. Conditional silencing: the HMRE mating-type silencer exerts a rapidly reversible position effect on the yeast HSP82 heat shock gene. Lee S, et al. Mol Cell Biol, 1993 Feb. PMID 8423797, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mating-type specific transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Hmra1p
    NP_010021.1
    • Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      293835..294321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178804.1 → NP_010021.1  TPA: Hmra1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010021.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR98, P01366, P09091, P0CY10, P0CY11, Q06724
      UniProtKB/TrEMBL
      B3LUF0, C7GSB0, C8Z4D0
      Conserved Domains (1) summary
      smart00389
      Location:70 → 126
      HOX; Homeodomain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CY11.1

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