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    ADI1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855021, updated on 22-Aug-2024

    Summary

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    Official Symbol
    ADI1
    Primary source
    FungiDB:YMR009W
    Locus tag
    YMR009W
    See related
    SGD:S000004611; AllianceGenome:SGD:S000004611; VEuPathDB:YMR009W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables acireductone dioxygenase (Ni2+-requiring) activity. Involved in L-methionine salvage from methylthioadenosine. Located in cytoplasm and nucleus. Orthologous to human ADI1 (acireductone dioxygenase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (284102..284641)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene lysophospholipase Neighboring gene uncharacterized protein Neighboring gene Any1p Neighboring gene hexose transporter HXT2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. Hirano W, et al. Genes Cells, 2005 Jun. PMID 15938715
    2. Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation. Zer C, et al. J Biol Chem, 2005 Aug 12. PMID 15967792
    3. A complete inventory of all enzymes in the eukaryotic methionine salvage pathway. Pirkov I, et al. FEBS J, 2008 Aug. PMID 18625006
    4. Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production. Blazeck J, et al. Appl Microbiol Biotechnol, 2014 Oct. PMID 24997118
    5. Capturing the Asc1p/Receptor for Activated C Kinase 1 (RACK1) Microenvironment at the Head Region of the 40S Ribosome with Quantitative BioID in Yeast. Opitz N, et al. Mol Cell Proteomics, 2017 Dec. PMID 28982715, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MTCBP-1 acts as a eukaryotic aci-reductone dioxygenase in the methionine salvage pathway.
      Title: Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acireductone dioxygenase (Ni2+-requiring) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acireductone dioxygenase (Ni2+-requiring) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acireductone dioxygenase [iron(II)-requiring] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acireductone dioxygenase [iron(II)-requiring] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nickel cation binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-methionine salvage from methylthioadenosine IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in L-methionine salvage from methylthioadenosine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in L-methionine salvage from methylthioadenosine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methionine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acireductone dioxygenase (Ni2+-requiring)
    NP_013722.1
    • Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; human ortholog ADI1 can complement yeast adi1 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      284102..284641
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182505.1 → NP_013722.1  TPA: acireductone dioxygenase (Ni2+-requiring) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZI3, Q03677
      UniProtKB/TrEMBL
      A6ZM70, B3LLR0, B5VPD5, C7GLB0, C8ZEL5, G2WK60, N1NY62
      Conserved Domains (1) summary
      COG1791
      Location:1 → 179
      Adi1; Acireductone dioxygenase (methionine salvage), cupin superfamily [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03677.1

    Gene LinkOut

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