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    OAC1 Oac1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853739, updated on 18-Sep-2024

    Summary

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    Official Symbol
    OAC1
    Official Full Name
    Oac1p
    Primary source
    SGD:S000001603
    Locus tag
    YKL120W
    See related
    AllianceGenome:SGD:S000001603; FungiDB:YKL120W; VEuPathDB:YKL120W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables dicarboxylic acid transmembrane transporter activity and sulfate transmembrane transporter activity. Involved in isopropylmalate transport; oxaloacetate transport; and sulfate transport. Located in mitochondrial inner membrane. Orthologous to several human genes including SLC25A35 (solute carrier family 25 member 35). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OAC1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (217344..218318)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene signal recognition particle subunit SRP21 Neighboring gene Dgr2p Neighboring gene Vph2p Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. alpha-Isopropylmalate, a leucine biosynthesis intermediate in yeast, is transported by the mitochondrial oxalacetate carrier. Marobbio CM, et al. J Biol Chem, 2008 Oct 17. PMID 18682385, Free PMC Article
    2. Identification of the yeast mitochondrial transporter for oxaloacetate and sulfate. Palmieri L, et al. J Biol Chem, 1999 Aug 6. PMID 10428783
    3. A critical tyrosine residue determines the uncoupling protein-like activity of the yeast mitochondrial oxaloacetate carrier. Luévano-Martínez LA, et al. Biochem J, 2012 Apr 1. PMID 22236206
    4. Mitochondrial Compartmentalization Confers Specificity to the 2-Ketoacid Recursive Pathway: Increasing Isopentanol Production in Saccharomyces cerevisiae. Hammer SK, et al. ACS Synth Biol, 2020 Mar 20. PMID 32049515
    5. Iterative algorithm-guided design of massive strain libraries, applied to itaconic acid production in yeast. Young EM, et al. Metab Eng, 2018 Jul. PMID 29753070

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isopropylmalate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables malonate(1-) transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxaloacetate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in isopropylmalate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in malonic acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oxaloacetate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oxaloacetate(2-) transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Oac1p
    NP_012802.1
    • Mitochondrial inner membrane transporter; transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      217344..218318
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179686.1 → NP_012802.1  TPA: Oac1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012802.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXH0, P32332
      UniProtKB/TrEMBL
      A6ZZJ9, B3LQX8, B5VM41, C7GVJ4, C8ZC55, G2WHR6, N1P308
      Conserved Domains (1) summary
      PTZ00169
      Location:26 → 294
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32332.1

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