Ddx25 DEAD-box helicase 25 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ddx25provided by RGD
Official Full Name: DEAD-box helicase 25provided by RGD
Primary source: RGD:68381
See related: EnsemblRapid:ENSRNOG00000012260 AllianceGenome:RGD:68381
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GRTH
Summary: Enables ATP hydrolysis activity; RNA binding activity; and RNA helicase activity. Predicted to be involved in poly(A)+ mRNA export from nucleus; regulation of translation; and spermatid development. Located in cytoplasm and nucleus. Orthologous to human DDX25 (DEAD-box helicase 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 633.1) and Brain (RPKM 116.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 8q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (42152046..42168635, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (33894224..33910377, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (36744686..36760720, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results suggest that DDX25 functions in meiotic cells,intermitochondrial cement,loose aggregates of particles,chromatoid bodies,late chromatoid bodies,satellite bodies,granulated bodies,mitochondria-associated granules and reticulated bodies.
Title: Expression of DDX25 in nuage components of mammalian spermatogenic cells: immunofluorescence and immunoelectron microscopic study.
studies on GRTH [proide insights into the intrinsic requirements of spermatogenesis and open new avenues for studies on regulating spermatogenesis, infertility and male contraception
Title: Gonadotropin-regulated testicular helicase (GRTH/DDX25): a master post-transcriptional regulator of spermatogenesis.
The results of this study indicate that the mammalian GRTH/Ddx25 gene is a multifunctional RNA helicase that is an essential regulator of sperm maturation.
Title: Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a transport protein involved in gene-specific mRNA export and protein translation during spermatogenesis.
expression is regulated by gonadotropin/androgen at the translational level
Title: Cell-specific and hormone-regulated expression of gonadotropin-regulated testicular RNA helicase gene (GRTH/Ddx25) resulting from alternative utilization of translation initiation codons in the rat testis.

Submit: New GeneRIF Correction

General gene information

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Markers

BQ201435 (e-PCR)
- UniSTS:260705

RH132914 (e-PCR)
- UniSTS:216197

AW047046 (e-PCR)
- UniSTS:179873

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatid development	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in chromatoid body	ISO Inferred from Sequence Orthology more info
located_in chromatoid body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic stress granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DDX25

Names: DEAD (Asp-Glu-Ala-Asp) box helicase 25; DEAD (Asp-Glu-Ala-Asp) box polypeptide 25; DEAD (aspartate-glutamate-alanine-aspartate) box polypeptide 25; DEAD box protein 25; gonadotropin-regulated testicular RNA helicase

NP_113818.2

EC 3.6.4.13

XP_038937962.1

EC 3.6.4.13

XP_038937963.1

EC 3.6.4.13

XP_038937964.1

EC 3.6.4.13

XP_063122118.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031630.2 → NP_113818.2 ATP-dependent RNA helicase DDX25

See identical proteins and their annotated locations for NP_113818.2

Status: PROVISIONAL

Source sequence(s)

AF142629

UniProtKB/Swiss-Prot

Q9QY16

UniProtKB/TrEMBL

A6JYK6, F7ER47, Q68G14

Related

ENSRNOP00000017307.3, ENSRNOT00000017307.6

Conserved Domains (3) summary

smart00487
Location:112 → 315

DEXDc; DEAD-like helicases superfamily

cd00079
Location:311 → 447

HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...

cl21455
Location:111 → 301

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

42152046..42168635 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063266048.1 → XP_063122118.1 ATP-dependent RNA helicase DDX25 isoform X1

UniProtKB/TrEMBL

A0A8I6GG37
XM_039082036.2 → XP_038937964.1 ATP-dependent RNA helicase DDX25 isoform X1

UniProtKB/TrEMBL

A0A8I6GG37

Conserved Domains (2) summary

cd18787
Location:198 → 334

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

cl28899
Location:1 → 194

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
XM_039082034.2 → XP_038937962.1 ATP-dependent RNA helicase DDX25 isoform X1

UniProtKB/TrEMBL

A0A8I6GG37

Conserved Domains (2) summary

cd18787
Location:198 → 334

SF2_C_DEAD; C-terminal helicase domain of the DEAD box helicases

cl28899
Location:1 → 194

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
XM_039082035.2 → XP_038937963.1 ATP-dependent RNA helicase DDX25 isoform X2

UniProtKB/TrEMBL

A6JYK8

Conserved Domains (1) summary

cl28899
Location:80 → 266

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily