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    Cym chymosin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 56825, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Cymprovided by RGD
    Official Full Name
    chymosinprovided by RGD
    Primary source
    RGD:708486
    See related
    EnsemblRapid:ENSRNOG00000018236 AllianceGenome:RGD:708486
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 4.2), Testes (RPKM 2.0) and 5 other tissues See more
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    Genomic context

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    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (197516947..197527307, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (194828739..194839096, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (209962848..209973205, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100911 Neighboring gene potassium voltage-gated channel subfamily A member 10 Neighboring gene uncharacterized LOC102557194 Neighboring gene prokineticin 1 Neighboring gene uncharacterized LOC134485948

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of neonate/infant-specific pepsinogens from rat stomach mucosa and their expressional change during development. Kageyama T, et al. Biochem Biophys Res Commun, 2000 Jan 27. PMID 10673373
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    embryonic pepsinogen
    Names
    prochymosin
    NP_064476.2
    XP_038958924.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020091.2 → NP_064476.2  embryonic pepsinogen precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6HUT0, G3V8C5, Q9JJX1
      Related
      ENSRNOP00000024593.2, ENSRNOT00000024593.4
      Conserved Domains (2) summary
      pfam07966
      Location:19 → 47
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:64 → 377
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      197516947..197527307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102996.2 → XP_038958924.1  embryonic pepsinogen isoform X1

      UniProtKB/TrEMBL
      Q9JJX1
      Related
      ENSRNOP00000105070.1, ENSRNOT00000127485.1
      Conserved Domains (2) summary
      pfam07966
      Location:7 → 35
      A1_Propeptide; A1 Propeptide
      cl11403
      Location:52 → 365
      pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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