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    Csrp1 cysteine and glycine-rich protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29276, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Csrp1provided by RGD
    Official Full Name
    cysteine and glycine-rich protein 1provided by RGD
    Primary source
    RGD:62053
    See related
    EnsemblRapid:ENSRNOG00000008937 AllianceGenome:RGD:62053
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Csrp
    Summary
    Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle tissue development; platelet aggregation; and sarcomere organization. Predicted to be active in Z disc and nucleus. Orthologous to human CSRP1 (cysteine and glycine rich protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 2486.7), Uterus (RPKM 1310.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    13q13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49709928..49731141)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (47158171..47179388)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52553843..52575054)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene neuron navigator 1 Neighboring gene uncharacterized LOC120096254 Neighboring gene uncharacterized LOC102553722 Neighboring gene ribosomal protein L11, pseudogene 12 Neighboring gene uncharacterized LOC134481563 Neighboring gene pleckstrin homology-like domain, family A, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Isolation and developmental expression of a rat cDNA encoding a cysteine-rich zinc finger protein. McLaughlin CR, et al. Nucleic Acids Res, 1994 Dec 11. PMID 7816640, Free PMC Article
    2. cDNA cloning of the basement membrane chondroitin sulfate proteoglycan core protein, bamacan: a five domain structure including coiled-coil motifs. Wu RR, et al. J Cell Biol, 1997 Jan 27. PMID 9015313, Free PMC Article
    3. Analysis of the human cysteine-rich protein gene (CSRP), assignment to chromosome 1q24-1q32, and identification of an associated MspI polymorphism. Wang X, et al. Genomics, 1992 Oct. PMID 1385304
    4. Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures. Knierim E, et al. Am J Hum Genet, 2016 Mar 3. PMID 26924529, Free PMC Article
    5. Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes. Fröbel J, et al. Mol Cell Proteomics, 2013 May. PMID 23382103, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actinin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in platelet aggregation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in sarcomere organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cysteine and glycine-rich protein 1
    Names
    CRP
    CRP1
    Csrp 1
    cysteine rich protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017148.2 → NP_058844.1  cysteine and glycine-rich protein 1

      See identical proteins and their annotated locations for NP_058844.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062407
      UniProtKB/Swiss-Prot
      P47875
      UniProtKB/TrEMBL
      A0A8L2Q5C4, A6ICG1
      Related
      ENSRNOP00000011991.5, ENSRNOT00000011991.7
      Conserved Domains (2) summary
      cd09403
      Location:119 → 172
      LIM2_CRP; The second LIM domain of Cysteine Rich Protein (CRP)
      cd09479
      Location:8 → 63
      LIM1_CRP1; The first LIM domain of Cysteine Rich Protein 1 (CRP1)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      49709928..49731141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47875.2 GenPept UniProtKB/Swiss-Prot:P47875

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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