Tsen15 tRNA splicing endonuclease subunit 15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tsen15provided by RGD
Official Full Name: tRNA splicing endonuclease subunit 15provided by RGD
Primary source: RGD:1308584
See related: EnsemblRapid:ENSRNOG00000002352 AllianceGenome:RGD:1308584
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308584
Summary: Predicted to enable nuclease activity and nucleic acid binding activity. Predicted to be involved in nucleic acid phosphodiester bond hydrolysis and tRNA splicing, via endonucleolytic cleavage and ligation. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia. Orthologous to human TSEN15 (tRNA splicing endonuclease subunit 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 166.4), Muscle (RPKM 148.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (67040134..67055509, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (64490216..64505591, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (69765093..69781019, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in tRNA splicing, via endonucleolytic cleavage and ligation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA-splicing endonuclease subunit Sen15

Names: TSEN15 tRNA splicing endonuclease subunit; tRNA splicing endonuclease 15 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.