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    Orc6 origin recognition complex, subunit 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291927, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Orc6provided by RGD
    Official Full Name
    origin recognition complex, subunit 6provided by RGD
    Primary source
    RGD:1311437
    See related
    EnsemblRapid:ENSRNOG00000024043 AllianceGenome:RGD:1311437
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Orc6l
    Summary
    Predicted to enable DNA binding activity. Predicted to be involved in DNA replication initiation and negative regulation of cell division. Predicted to act upstream of or within DNA-dependent DNA replication. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of nuclear origin of replication recognition complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 3. Orthologous to human ORC6 (origin recognition complex subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 68.5), Spleen (RPKM 59.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Orc6 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (37931085..37938856, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (21757867..21765638, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (27457541..27464804, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S11, pseudogene 2 Neighboring gene uncharacterized LOC134483311 Neighboring gene myosin light chain kinase 3 Neighboring gene VPS35 retromer complex component Neighboring gene U6 spliceosomal RNA Neighboring gene mitogen-activated protein kinase 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Recruitment of Orc6l, a dormant maternal mRNA in mouse oocytes, is essential for DNA replication in 1-cell embryos. Murai S, et al. Dev Biol, 2010 May 1. PMID 20219456, Free PMC Article
    2. Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Varma D, et al. Nat Cell Biol, 2012 May 13. PMID 22581055, Free PMC Article
    3. ATP-dependent assembly of the human origin recognition complex. Siddiqui K, et al. J Biol Chem, 2007 Nov 2. PMID 17716973
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124771

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA-templated DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033690.1 → NP_001028862.1  origin recognition complex subunit 6

      See identical proteins and their annotated locations for NP_001028862.1

      Status: PROVISIONAL

      Source sequence(s)
      BC101871
      UniProtKB/TrEMBL
      F7FAH8, Q3T1K3
      Related
      ENSRNOP00000035958.6, ENSRNOT00000039467.7
      Conserved Domains (3) summary
      cd11583
      Location:94 → 186
      Orc6_mid; Middle domain of the origin recognition complex subunit 6
      pfam05460
      Location:9 → 94
      ORC6; Origin recognition complex subunit 6 (ORC6)
      cd16075
      Location:210 → 259
      ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      37931085..37938856 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277872.1 → XP_063133942.1  origin recognition complex subunit 6 isoform X1

    2. XM_063277873.1 → XP_063133943.1  origin recognition complex subunit 6 isoform X2

      UniProtKB/TrEMBL
      A6KDE7
    Nucleotide Protein Strain
    Heading Accession and Version

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