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    Lamc2 laminin subunit gamma 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192362, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Lamc2provided by RGD
    Official Full Name
    laminin subunit gamma 2provided by RGD
    Primary source
    RGD:621053
    See related
    EnsemblRapid:ENSRNOG00000002667 AllianceGenome:RGD:621053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heparin binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including neuron projection development; positive regulation of cell migration; and positive regulation of cell population proliferation. Located in several cellular components, including cell cortex; extracellular space; and perinuclear region of cytoplasm. Part of laminin-2 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa; junctional epidermolysis bullosa Herlitz type; junctional epidermolysis bullosa non-Herlitz type; and lung small cell carcinoma. Orthologous to human LAMC2 (laminin subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 136.0), Heart (RPKM 95.4) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lamc2 in Genome Data Viewer
    Location:
    13q21
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (67835199..67894694, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (65284664..65344164, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (70566643..70632126, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481571 Neighboring gene ribosomal protein S2, pseudogene 37 Neighboring gene uncharacterized LOC120096279 Neighboring gene nicotinamide nucleotide adenylyltransferase 2 Neighboring gene laminin subunit gamma 1 Neighboring gene ornithine decarboxylase-like Neighboring gene SHC binding and spindle associated 1 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Serum LAMC2 enhances the prognostic value of a multi-parametric panel in non-small cell lung cancer. Korbakis D, et al. Br J Cancer, 2015 Jul 28. PMID 26180921, Free PMC Article
    2. Laminin-5γ2 chain expression is associated with tumor cell invasiveness and prognosis of lung squamous cell carcinoma. Masuda R, et al. Biomed Res, 2012. PMID 23124251
    3. Differential localization of laminin gamma and integrin beta in primary cultures of the rat gingival epithelium. Tanno M, et al. J Periodontal Res, 2006 Feb. PMID 16409251
    4. Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa. Pulkkinen L, et al. Nat Genet, 1994 Mar. PMID 8012393
    5. LAMC2 enhances the metastatic potential of lung adenocarcinoma. Moon YW, et al. Cell Death Differ, 2015 Aug. PMID 25591736, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study aimed to identify genomic biomarkers for early and sensitive detection of renal papillary injury in rats; Timp1, Igf1, and Lamc2 exhibited the best prediction performance
      Title: Toxicogenomic biomarkers for renal papillary injury in rats.
    2. Binding sites for alpha3beta1 and alpha6beta4 are closely spaced in the Ln-332 LG domains where they regulate alternative cell functions, namely adhesion/migration or hemidesmosome anchoring.
      Title: Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain.
    3. In bladder carcinoma laminin-332 can suppress the number of invadopodia that form by interacting with a3b1 integrin and altering the cellular balance of FAK and Src kinase activity.
      Title: Laminin-332-beta1 integrin interactions negatively regulate invadopodia.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of laminin-2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of laminin-5 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    laminin subunit gamma-2
    Names
    lamimin, gamma 2
    laminin, gamma 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100640.3 → NP_001094110.1  laminin subunit gamma-2 precursor

      See identical proteins and their annotated locations for NP_001094110.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1LRH4
      Related
      ENSRNOP00000037099.5, ENSRNOT00000036947.7
      Conserved Domains (7) summary
      cl14654
      Location:1039 → 1159
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00281
      Location:245 → 370
      LamB; Laminin B domain
      COG0840
      Location:769 → 1165
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd00055
      Location:83 → 127
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00185
      Location:445 → 481
      TNFRSF; CRD2 [structural motif]
      pfam00053
      Location:139 → 184
      Laminin_EGF; Laminin EGF domain
      cl22855
      Location:437 → 501
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      67835199..67894694 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769603.4 → XP_008767825.1  laminin subunit gamma-2 isoform X1

      See identical proteins and their annotated locations for XP_008767825.1

      UniProtKB/TrEMBL
      F1LRH4
      Related
      ENSRNOP00000099868.1, ENSRNOT00000131794.1
      Conserved Domains (7) summary
      cl14654
      Location:1039 → 1159
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00281
      Location:245 → 370
      LamB; Laminin B domain
      COG0840
      Location:769 → 1165
      Tar; Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms]
      cd00055
      Location:83 → 127
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00185
      Location:445 → 481
      TNFRSF; CRD2 [structural motif]
      pfam00053
      Location:139 → 184
      Laminin_EGF; Laminin EGF domain
      cl22855
      Location:437 → 501
      TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    Nucleotide Protein Strain
    Heading Accession and Version

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