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    Pitpnm3 PITPNM family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287467, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Pitpnm3provided by RGD
    Official Full Name
    PITPNM family member 3provided by RGD
    Primary source
    RGD:1308200
    See related
    EnsemblRapid:ENSRNOG00000008323 AllianceGenome:RGD:1308200
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity; phospholipase activity; and receptor tyrosine kinase binding activity. Located in cell body and cell projection. Human ortholog(s) of this gene implicated in cone-rod dystrophy 5. Orthologous to human PITPNM3 (PITPNM family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 66.5), Lung (RPKM 59.2) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pitpnm3 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (57173230..57265186, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (56674697..56766552, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (58618679..58722679, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134478829 Neighboring gene aryl hydrocarbon receptor-interacting protein-like 1 Neighboring gene PICALM interacting mitotic regulator Neighboring gene RIKEN cDNA 4933427D14 gene like Neighboring gene uncharacterized LOC134480818 Neighboring gene thioredoxin domain containing 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. Lev S, et al. Mol Cell Biol, 1999 Mar. PMID 10022914, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phospholipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    membrane-associated phosphatidylinositol transfer protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430113.1 → NP_001417042.1  membrane-associated phosphatidylinositol transfer protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HGD7, M0RDK4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      57173230..57265186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087319.2 → XP_038943247.1  membrane-associated phosphatidylinositol transfer protein 3 isoform X1

      Related
      ENSRNOP00000067705.3, ENSRNOT00000071764.5
      Conserved Domains (2) summary
      smart00775
      Location:739 → 869
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      pfam02862
      Location:393 → 593
      DDHD; DDHD domain

    2. XM_063270035.1 → XP_063126105.1  membrane-associated phosphatidylinositol transfer protein 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTJ8, A6HGD7
      Related
      ENSRNOP00000081683.1, ENSRNOT00000120205.2

    3. XM_039087320.2 → XP_038943248.1  membrane-associated phosphatidylinositol transfer protein 3 isoform X4

      Conserved Domains (2) summary
      smart00775
      Location:317 → 447
      LNS2; This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain and phosphatidylinositol transfer proteins
      pfam02862
      Location:2 → 171
      DDHD; DDHD domain

    4. XM_063270036.1 → XP_063126106.1  membrane-associated phosphatidylinositol transfer protein 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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