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    Zbtb7b zinc finger and BTB domain containing 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295248, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Zbtb7bprovided by RGD
    Official Full Name
    zinc finger and BTB domain containing 7Bprovided by RGD
    Primary source
    RGD:1305963
    See related
    EnsemblRapid:ENSRNOG00000020640 AllianceGenome:RGD:1305963
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zfp67
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of alpha-beta T cell activation. Predicted to act upstream of or within regulation of alpha-beta T cell differentiation and regulation of gene expression. Predicted to be located in nucleoplasm. Orthologous to human ZBTB7B (zinc finger and BTB domain containing 7B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 135.7), Adrenal (RPKM 122.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (177093569..177111894, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174795831..174811980, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188704989..188719674, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 15 Neighboring gene DC-STAMP domain containing 1 Neighboring gene DC-STAMP domain containing 2 Neighboring gene lens epithelial protein Neighboring gene flavin adenine dinucleotide synthetase 1 Neighboring gene CDC28 protein kinase regulatory subunit 1B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Th-POK regulates mammary gland lactation through mTOR-SREBP pathway. Zhang R, et al. PLoS Genet, 2018 Feb. PMID 29420538, Free PMC Article
    2. ZBTB7B (Th-POK) regulates the development of IL-17-producing CD1d-restricted mouse NKT cells. Enders A, et al. J Immunol, 2012 Dec 1. PMID 23105140, Free PMC Article
    3. c-Krox binds to several sites in the promoter of both mouse type I collagen genes. Structure/function study and developmental expression analysis. Galéra P, et al. J Biol Chem, 1996 Aug 30. PMID 8702912
    4. c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin. Galéra P, et al. Proc Natl Acad Sci U S A, 1994 Sep 27. PMID 7937772, Free PMC Article
    5. The transcription factor ThPOK suppresses Runx3 and imposes CD4(+) lineage fate by inducing the SOCS suppressors of cytokine signaling. Luckey MA, et al. Nat Immunol, 2014 Jul. PMID 24880459, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NK T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adaptive thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lactation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of CD8-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of NK T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of T-helper 17 cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of SREBP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-17 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of CD8-positive, alpha-beta T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of T-helper cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to insulin ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 7B
    Names
    zinc finger protein 67

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106446.1 → NP_001099916.1  zinc finger and BTB domain-containing protein 7B

      See identical proteins and their annotated locations for NP_001099916.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473976
      UniProtKB/TrEMBL
      A6J6F5
      Conserved Domains (3) summary
      COG5048
      Location:232 → 311
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:250 → 272
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      177093569..177111894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761136.4 → XP_008759358.1  zinc finger and BTB domain-containing protein 7B isoform X2

      See identical proteins and their annotated locations for XP_008759358.1

      UniProtKB/TrEMBL
      D4A579
      Conserved Domains (4) summary
      COG5048
      Location:349 → 428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380 → 400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18327
      Location:9 → 142
      BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
      pfam13465
      Location:367 → 389
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006232614.5 → XP_006232676.1  zinc finger and BTB domain-containing protein 7B isoform X2

      See identical proteins and their annotated locations for XP_006232676.1

      UniProtKB/TrEMBL
      D4A579
      Related
      ENSRNOP00000028010.7, ENSRNOT00000028010.9
      Conserved Domains (4) summary
      COG5048
      Location:349 → 428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380 → 400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18327
      Location:9 → 142
      BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
      pfam13465
      Location:367 → 389
      zf-H2C2_2; Zinc-finger double domain

    3. XM_008761137.4 → XP_008759359.1  zinc finger and BTB domain-containing protein 7B isoform X2

      See identical proteins and their annotated locations for XP_008759359.1

      UniProtKB/TrEMBL
      D4A579
      Conserved Domains (4) summary
      COG5048
      Location:349 → 428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380 → 400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18327
      Location:9 → 142
      BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
      pfam13465
      Location:367 → 389
      zf-H2C2_2; Zinc-finger double domain

    4. XM_039102042.2 → XP_038957970.1  zinc finger and BTB domain-containing protein 7B isoform X1

      Conserved Domains (4) summary
      COG5048
      Location:403 → 482
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:434 → 454
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18327
      Location:63 → 196
      BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
      pfam13465
      Location:421 → 443
      zf-H2C2_2; Zinc-finger double domain

    5. XM_017590764.3 → XP_017446253.1  zinc finger and BTB domain-containing protein 7B isoform X2

      UniProtKB/TrEMBL
      D4A579
      Conserved Domains (4) summary
      COG5048
      Location:349 → 428
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:380 → 400
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18327
      Location:9 → 142
      BTB_POZ_ZBTB7B_ZBTB15; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B)
      pfam13465
      Location:367 → 389
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version

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