Cckar cholecystokinin A receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cckarprovided by RGD
Official Full Name: cholecystokinin A receptorprovided by RGD
Primary source: RGD:2289
See related: EnsemblRapid:ENSRNOG00000043124 AllianceGenome:RGD:2289
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cck-ar
Summary: Enables cholecystokinin receptor activity. Involved in several processes, including positive regulation of somatostatin secretion; reduction of food intake in response to dietary excess; and regulation of metal ion transport. Located in several cellular components, including endosome; lysosome; and terminal bouton. Used to study obesity and type 2 diabetes mellitus. Biomarker of pancreatic cancer. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CCKAR (cholecystokinin A receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 12.6), Liver (RPKM 3.7) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (61505270..61513618)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (57292397..57300747)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (59610939..59619786)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats.
Title: Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats.
Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade.
Title: Spinal CCK1 Receptors Contribute to Somatic Pain Hypersensitivity Induced by Malocclusion via a Reciprocal Neuron-Glial Signaling Cascade.
The critical role of CCK in the regulation of food intake and diet-induced obesity.
Title: The critical role of CCK in the regulation of food intake and diet-induced obesity.
Satiety induced by bile acids is mediated via vagal afferent pathways.
Title: Satiety induced by bile acids is mediated via vagal afferent pathways.
This study demonistrated that Cckar and Melanin-concentrating hormone colization in neuron in the lateral hypothalamus (LH) and zona incerta (ZI), but MCHR1 mRNA is widely expressed throughout the brain.
Title: Identification of neuropeptide receptors expressed by melanin-concentrating hormone neurons.
Data suggest that Apo AIV (apolipoprotein AIV) in NTS (nucleus of the solitary tract) or/and peripheral Cck (cholecystokinin) require vagal Cck1r/Cckar signaling to elicit satiation; high-fat diet reduces satiating capacity of these signals.
Title: Intraperitoneal CCK and fourth-intraventricular Apo AIV require both peripheral and NTS CCK1R to reduce food intake in male rats.
factors secondary to obesity and/or diabetes rather than impaired CCK-1 receptor signaling may contribute to altered CART expression
Title: Cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactivity in feeding- and reward-related brain areas of young OLETF rats.
CCK-A receptors are located on the cell bodies of cholinergic interneurons in the corpus striatum.
Title: Modulation of acetylcholine release by cholecystokinin in striatum: receptor specificity; role of dopaminergic neuronal activity.
Activation of duodenal PKC-delta leads to the stimulation of CCK release and activation of the CCK-A receptor signaling axis to lower glucose production in normal rats.
Title: Duodenal PKC-δ and cholecystokinin signaling axis regulates glucose production.
Data indicate that the Homo-Phe derivative 2 (VL-0797) enhanced 12-fold the affinity for the rat CCK(1)-R affinity and 15-fold for the human CCK(1)-R relative to the reference compound 12 (VL-0395).
Title: New anthranilic acid based antagonists with high affinity and selectivity for the human cholecystokinin receptor 1 (hCCK1-R).

Submit: New GeneRIF Correction See all GeneRIFs (47)

General gene information

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Markers

PMC129753P2 (e-PCR)
- UniSTS:270600

D14Wox24 (e-PCR)
- UniSTS:239605

D14Wox25 (e-PCR)
- UniSTS:239606

D14Wox26 (e-PCR)
- UniSTS:239607

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cholecystokinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cholecystokinin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables cholecystokinin receptor activity	IEA Inferred from Electronic Annotation more info
enables cholecystokinin receptor activity	ISO Inferred from Sequence Orthology more info
enables cholecystokinin receptor activity	TAS Traceable Author Statement more info	PubMed
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables peptide hormone binding	IEA Inferred from Electronic Annotation more info
enables peptide hormone binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cholecystokinin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cholecystokinin signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in forebrain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in gastric acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in pancreas development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of somatostatin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reduction of food intake in response to dietary excess	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of hormone secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to steroid hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in temperature homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cholecystokinin receptor type A

Names: CCK-A receptor; CCK1-R; cholecystokinin-1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012688.3 → NP_036820.1 cholecystokinin receptor type A

See identical proteins and their annotated locations for NP_036820.1

Status: PROVISIONAL

Source sequence(s)

M88096

UniProtKB/Swiss-Prot

P30551

UniProtKB/TrEMBL

F1LQR7

Related

ENSRNOP00000063137.2, ENSRNOT00000065366.4

Conserved Domains (3) summary

pfam09193
Location:16 → 62

CholecysA-Rec_N; Cholecystokinin A receptor, N-terminal

cd14964
Location:58 → 84

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:57 → 397

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily