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    Osbpl5 oxysterol binding protein-like 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361686, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Osbpl5provided by RGD
    Official Full Name
    oxysterol binding protein-like 5provided by RGD
    Primary source
    RGD:1308402
    See related
    EnsemblRapid:ENSRNOG00000020713 AllianceGenome:RGD:1308402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including cholesterol binding activity; phosphatidylserine transfer activity; and phospholipid binding activity. Predicted to be involved in phospholipid transport. Predicted to be located in endoplasmic reticulum-plasma membrane contact site. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Orthologous to human OSBPL5 (oxysterol binding protein like 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 118.3), Kidney (RPKM 62.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Osbpl5 in Genome Data Viewer
    Location:
    1q42
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (208291441..208362086, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (198862071..198916469, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (216866263..216920625, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene tumor necrosis factor receptor superfamily, member 26 Neighboring gene tumor necrosis factor receptor superfamily, member 22 Neighboring gene MAS related GPR family member G like 1 Neighboring gene MAS related GPR family member G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. INTRACELLULAR TRANSPORT. PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts. Chung J, et al. Science, 2015 Jul 24. PMID 26206935, Free PMC Article
    2. Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Maeda K, et al. Nature, 2013 Sep 12. PMID 23934110
    3. Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells. Sandhu J, et al. Cell, 2018 Oct 4. PMID 30220461, Free PMC Article
    4. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Suchanek M, et al. Biochem J, 2007 Aug 1. PMID 17428193, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109308

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermembrane lipid transfer IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    oxysterol-binding protein-related protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015024.2 → NP_001015024.2  oxysterol-binding protein-related protein 5

      See identical proteins and their annotated locations for NP_001015024.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JV78, A6HYD0, G3V8S8
      Related
      ENSRNOP00000028119.5, ENSRNOT00000028119.7
      Conserved Domains (3) summary
      cd13286
      Location:144 → 272
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:151 → 267
      PH; PH domain
      pfam01237
      Location:397 → 732
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      208291441..208362086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268111.1 → XP_063124181.1  oxysterol-binding protein-related protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JV78
      Related
      ENSRNOP00000082076.2, ENSRNOT00000100959.2

    2. XM_006230828.5 → XP_006230890.1  oxysterol-binding protein-related protein 5 isoform X2

      See identical proteins and their annotated locations for XP_006230890.1

      UniProtKB/TrEMBL
      A0A0G2JV78, A6HYD1
      Conserved Domains (3) summary
      cd13286
      Location:120 → 248
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:127 → 243
      PH; PH domain
      pfam01237
      Location:373 → 708
      Oxysterol_BP; Oxysterol-binding protein

    3. XM_006230830.5 → XP_006230892.1  oxysterol-binding protein-related protein 5 isoform X2

      See identical proteins and their annotated locations for XP_006230892.1

      UniProtKB/TrEMBL
      A0A0G2JV78, A6HYD1
      Conserved Domains (3) summary
      cd13286
      Location:120 → 248
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:127 → 243
      PH; PH domain
      pfam01237
      Location:373 → 708
      Oxysterol_BP; Oxysterol-binding protein

    4. XM_039083625.2 → XP_038939553.1  oxysterol-binding protein-related protein 5 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JV78
      Related
      ENSRNOP00000112749.1, ENSRNOT00000139372.1
      Conserved Domains (2) summary
      cd13286
      Location:49 → 177
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam01237
      Location:302 → 644
      Oxysterol_BP; Oxysterol-binding protein

    5. XM_006230829.5 → XP_006230891.1  oxysterol-binding protein-related protein 5 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZYG1
      Conserved Domains (3) summary
      cd13286
      Location:120 → 248
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:127 → 243
      PH; PH domain
      pfam01237
      Location:373 → 708
      Oxysterol_BP; Oxysterol-binding protein
    Nucleotide Protein Strain
    Heading Accession and Version

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