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    Gtf2e2 general transcription factor IIE subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306516, updated on 10-Jul-2024

    Summary

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    Official Symbol
    Gtf2e2provided by RGD
    Official Full Name
    general transcription factor IIE subunit 2provided by RGD
    Primary source
    RGD:1310134
    See related
    EnsemblRapid:ENSRNOG00000014422 AllianceGenome:RGD:1310134
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable RNA polymerase II general transcription initiation factor activity. Predicted to be involved in transcription initiation from RNA polymerase II promoter. Predicted to be located in cytosol and nuclear speck. Predicted to be part of transcription factor TFIID complex and transcription factor TFIIE complex. Human ortholog(s) of this gene implicated in nonphotosensitive trichothiodystrophy 6. Orthologous to human GTF2E2 (general transcription factor IIE subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 77.5), Spleen (RPKM 60.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf2e2 in Genome Data Viewer
    Location:
    16q12.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (65102386..65152563, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (58399307..58449467, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (62113846..62164339, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene RNA binding protein, mRNA processing factor Neighboring gene uncharacterized LOC120097493 Neighboring gene small integral membrane protein 18 Neighboring gene uncharacterized LOC120097494 Neighboring gene uncharacterized LOC134482513 Neighboring gene glutathione-disulfide reductase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural insights into transcription initiation by RNA polymerase II. Grünberg S, et al. Trends Biochem Sci, 2013 Dec. PMID 24120742, Free PMC Article
    2. Near-atomic resolution visualization of human transcription promoter opening. He Y, et al. Nature, 2016 May 19. PMID 27193682, Free PMC Article
    3. Gene expression analysis in response to lung toxicants: I. Sequencing and microarray development. Shultz MA, et al. Am J Respir Cell Mol Biol, 2004 Mar. PMID 12947022
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to TFIIH-class transcription factor complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor IIE subunit beta
    Names
    general transcription factor IIE, polypeptide 2 (beta subunit)
    general transcription factor IIE, polypeptide 2, beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107318.2 → NP_001100788.2  transcription initiation factor IIE subunit beta

      See identical proteins and their annotated locations for NP_001100788.2

      Status: VALIDATED

      Source sequence(s)
      BI293118, CF110694
      UniProtKB/TrEMBL
      D3ZCP9
      Related
      ENSRNOP00000055659.3, ENSRNOT00000058872.5
      Conserved Domains (2) summary
      cd07977
      Location:68 → 146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:146 → 204
      TFA2_Winged_2; TFA2 Winged helix domain 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      65102386..65152563 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006253230.5 → XP_006253292.1  transcription initiation factor IIE subunit beta isoform X1

      See identical proteins and their annotated locations for XP_006253292.1

      UniProtKB/TrEMBL
      D3ZCP9
      Conserved Domains (2) summary
      cd07977
      Location:68 → 146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:146 → 204
      TFA2_Winged_2; TFA2 Winged helix domain 2

    2. XM_039094546.2 → XP_038950474.1  transcription initiation factor IIE subunit beta isoform X1

      UniProtKB/TrEMBL
      D3ZCP9
      Conserved Domains (2) summary
      cd07977
      Location:68 → 146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
      pfam18121
      Location:146 → 204
      TFA2_Winged_2; TFA2 Winged helix domain 2

    3. XM_063275438.1 → XP_063131508.1  transcription initiation factor IIE subunit beta isoform X3

      Related
      ENSRNOP00000099792.1, ENSRNOT00000172458.1

    4. XM_006253231.5 → XP_006253293.1  transcription initiation factor IIE subunit beta isoform X2

      Conserved Domains (1) summary
      cd07977
      Location:68 → 146
      TFIIE_beta_winged_helix; TFIIE_beta_winged_helix domain, located at the central core region of TFIIE beta, with double-stranded DNA binding activity
    Nucleotide Protein Strain
    Heading Accession and Version

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