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    PRY1 sterol-binding protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853366, updated on 17-May-2024

    Summary

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    Gene symbol
    PRY1
    Gene description
    sterol-binding protein
    Primary source
    FungiDB:YJL079C
    Locus tag
    YJL079C
    See related
    SGD:S000003615; AllianceGenome:SGD:S000003615; VEuPathDB:YJL079C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cholesterol binding activity; fatty acid binding activity; and magnesium ion binding activity. Involved in fatty acid transport and sterol transport. Located in extracellular region. Orthologous to human GLIPR2 (GLI pathogenesis related 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PRY1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (289875..290774, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Arp4p Neighboring gene Scp160p Neighboring gene Pry3p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional characterization of the CAP domain of pathogen-related yeast 1 (Pry1) protein. Darwiche R, et al. Sci Rep, 2016 Jun 27. PMID 27344972, Free PMC Article
    2. The caveolin-binding motif of the pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is required for in vivo export of cholesteryl acetate. Choudhary V, et al. J Lipid Res, 2014 May. PMID 24598142, Free PMC Article
    3. The yeast cell wall protein Pry3 inhibits mating through highly conserved residues within the CAP domain. Cottier S, et al. Biol Open, 2020 Jul 2. PMID 32554483, Free PMC Article
    4. Mature lipid droplets are accessible to ER luminal proteins. Mishra S, et al. J Cell Sci, 2016 Oct 15. PMID 27591256
    5. Pathogen-Related Yeast (PRY) proteins and members of the CAP superfamily are secreted sterol-binding proteins. Choudhary V, et al. Proc Natl Acad Sci U S A, 2012 Oct 16. PMID 23027975, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cholesterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fatty acid binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sterol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in nuclear envelope HDA PubMed 

    General protein information

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    Preferred Names
    sterol-binding protein
    NP_012456.1
    • Lipid binding protein; binds to both free fatty acids with preference for saturated long-chain fatty acids and to sterols; contains two independent lipid-binding sites; involved in the export of free fatty acids and acetylated sterols; export functions are redundant with PRY2, and PRY3; important for survival of cells that accumulate free fatty acids; involved in detoxification of hydrophobic compounds; secreted glycoprotein and member of the CAP/SCP protein superfamily

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      289875..290774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181512.1 → NP_012456.1  TPA: sterol-binding protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012456.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWA4, P47032
      UniProtKB/TrEMBL
      A0A8H4BYG9, A6ZPP5, B3LQ33, B5VL98, C7GR34, C8ZBD3, N1P0U2
      Conserved Domains (1) summary
      cd05384
      Location:166 → 289
      CAP_PRY1-like; CAP (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins) domain of pathogen-related yeast 1 (PRY1) protein and similar fungal proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47032.1

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