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    TPS2 trehalose-phosphatase TPS2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851646, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TPS2
    Official Full Name
    trehalose-phosphatase TPS2
    Primary source
    SGD:S000002481
    Locus tag
    YDR074W
    See related
    AllianceGenome:SGD:S000002481; FungiDB:YDR074W; VEuPathDB:YDR074W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HOG2; PFK3
    Summary
    Enables trehalose-phosphatase activity. Involved in several processes, including cellular response to heat; protein dephosphorylation; and trehalose metabolic process. Located in mitochondrion. Part of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TPS2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (593893..596583)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene inositolphosphotransferase Neighboring gene Snf11p Neighboring gene phosphoprotein phosphatase PP4 catalytic subunit PPH3 Neighboring gene putative DNA-dependent ATPase RAD55

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stratification of yeast cells during chronological aging by size points to the role of trehalose in cell vitality. Svenkrtova A, et al. Biogerontology, 2016 Apr. PMID 26614086, Free PMC Article
    2. Sphingolipids are potential heat stress signals in Saccharomyces. Dickson RC, et al. J Biol Chem, 1997 Nov 28. PMID 9374502
    3. Analysis of PFK3--a gene involved in particulate phosphofructokinase synthesis reveals additional functions of TPS2 in Saccharomyces cerevisiae. Sur IP, et al. Yeast, 1994 Feb. PMID 8203161
    4. Lost in transition: start-up of glycolysis yields subpopulations of nongrowing cells. van Heerden JH, et al. Science, 2014 Feb 28. PMID 24436182
    5. Yeast metabolic and signaling genes are required for heat-shock survival and have little overlap with the heat-induced genes. Gibney PA, et al. Proc Natl Acad Sci U S A, 2013 Nov 12. PMID 24167267, Free PMC Article

    See all (129) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Age-dependent decline in stress response capacity revealed by proteins dynamics analysis.
      Title: Age-dependent decline in stress response capacity revealed by proteins dynamics analysis.
    2. Tps3 must be phosphorylated by cAMP-dependent protein kinase, decreasing Tps2 activity and, consequently, increasing the concentration of T6P which would inhibit Tps1.
      Title: Regulation of the yeast trehalose-synthase complex by cyclic AMP-dependent phosphorylation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trehalose-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables trehalose-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables trehalose-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nitrogen starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trehalose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trehalose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in trehalose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in trehalose metabolism in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in trehalose metabolism in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    trehalose-phosphatase TPS2
    NP_010359.1
    • Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex; involved in the synthesis of storage carbohydrate trehalose; positive regulator of autophagy involved in the dephosphorylation of Rim15p leading to ATG8 induction; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      593893..596583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180382.1 → NP_010359.1  TPA: trehalose-phosphatase TPS2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010359.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS60, P31688
      UniProtKB/TrEMBL
      B3LGJ6, C8Z4Z2, N1P6I4
      Conserved Domains (2) summary
      TIGR00685
      Location:569 → 848
      T6PP; trehalose-phosphatase
      pfam00982
      Location:61 → 541
      Glyco_transf_20; Glycosyltransferase family 20
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31688.3

    Gene LinkOut

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