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    UBC11 putative E2 ubiquitin-protein ligase UBC11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854517, updated on 2-Nov-2024

    Summary

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    Official Symbol
    UBC11
    Official Full Name
    putative E2 ubiquitin-protein ligase UBC11
    Primary source
    SGD:S000005866
    Locus tag
    YOR339C
    See related
    AllianceGenome:SGD:S000005866; FungiDB:YOR339C; VEuPathDB:YOR339C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in anaphase-promoting complex-dependent catabolic process; protein polyubiquitination; and regulation of mitotic metaphase/anaphase transition. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human UBE2C (ubiquitin conjugating enzyme E2 C). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See UBC11 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (958362..958832, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Tea1p Neighboring gene uncharacterized protein Neighboring gene DNA-directed RNA polymerase I subunit RPA43 Neighboring gene DNA-directed RNA polymerase I core subunit RPA190

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of the Saccharomyces cerevisiae UBC11 gene. Townsley FM, et al. Yeast, 1998 Jun 15. PMID 9675819
    2. Proteasome Activity Is Influenced by the HECT_2 Protein Ipa1 in Budding Yeast. Lutz AP, et al. Genetics, 2018 May. PMID 29519818, Free PMC Article
    3. Ubiquitin-dependent protein degradation. Hochstrasser M. Annu Rev Genet, 1996. PMID 8982460
    4. Enhancement of stress tolerance in Saccharomyces cerevisiae by overexpression of ubiquitin ligase Rsp5 and ubiquitin-conjugating enzymes. Hiraishi H, et al. Biosci Biotechnol Biochem, 2006 Nov. PMID 17090950
    5. Tmc1 Is a Dynamically Regulated Effector of the Rpn4 Proteotoxic Stress Response. Guerra-Moreno A, et al. J Biol Chem, 2016 Jul 8. PMID 27226598, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mitotic metaphase/anaphase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative E2 ubiquitin-protein ligase UBC11
    NP_014984.3
    • Ubiquitin-conjugating enzyme; most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      958362..958832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183759.3 → NP_014984.3  TPA: putative E2 ubiquitin-protein ligase UBC11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014984.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W334, P52492
      UniProtKB/TrEMBL
      A6ZPG9, B3LJZ8, C7GNS7, C8ZH91, G2WNK1, N1NX16
      Conserved Domains (1) summary
      COG5078
      Location:11 → 156
      COG5078; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52492.1

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