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    RLP7 Rlp7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855730, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RLP7
    Official Full Name
    Rlp7p
    Primary source
    SGD:S000004947
    Locus tag
    YNL002C
    See related
    AllianceGenome:SGD:S000004947; FungiDB:YNL002C; VEuPathDB:YNL002C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPL7
    Summary
    Enables rRNA primary transcript binding activity. Involved in exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of preribosome, large subunit precursor. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RLP7 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (626174..627142, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mRNA-binding protein Neighboring gene Pet8p Neighboring gene ribosome dissociation factor DOM34 Neighboring gene citrate (Si)-synthase CIT1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rlp7p is associated with 60S preribosomes, restricted to the granular component of the nucleolus, and required for pre-rRNA processing. Gadal O, et al. J Cell Biol, 2002 Jun 10. PMID 12058014, Free PMC Article
    2. A nucleolar protein related to ribosomal protein L7 is required for an early step in large ribosomal subunit biogenesis. Dunbar DA, et al. Proc Natl Acad Sci U S A, 2000 Nov 21. PMID 11087857, Free PMC Article
    3. Two distinct yeast proteins are related to the mammalian ribosomal polypeptide L7. Lalo D, et al. Yeast, 1993 Oct. PMID 8256515
    4. Paralog-Specific Functions of RPL7A and RPL7B Mediated by Ribosomal Protein or snoRNA Dosage in Saccharomyces cerevisiae. Palumbo RJ, et al. G3 (Bethesda), 2017 Feb 9. PMID 28007835, Free PMC Article
    5. Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress. Gasch AP, et al. PLoS Biol, 2017 Dec. PMID 29240790, Free PMC Article

    See all (108) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rlp7 coevolved with RNA elements to facilitate eukaryotic-specific functions in ribosome assembly and pre-rRNA processing.
      Title: Identification of the binding site of Rlp7 on assembling 60S ribosomal subunits in Saccharomyces cerevisiae.
    2. Despite their predicted structural similarity, the data shows that Rlp7 and L7 clearly bind at different positions on the same pre-60S particles.
      Title: Yeast ribosomal protein L7 and its homologue Rlp7 are simultaneously present at distinct sites on pre-60S ribosomal particles.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables rRNA primary transcript binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rlp7p
    NP_014396.3
    • Nucleolar protein similar to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs; binds junction of ITS2 and ITS2-proximal stem between the 3' end of 5.8S rRNA and the 5' end of 25S rRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      626174..627142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182841.3 → NP_014396.3  TPA: Rlp7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014396.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1H5, P40693
      UniProtKB/TrEMBL
      B3LPP0, B5VR32, C7GJE1, C8ZFM4, N1NZN2
      Conserved Domains (1) summary
      cd01657
      Location:141 → 322
      Ribosomal_L7_archeal_euk; Ribosomal protein L7, which is found in archaea and eukaryotes but not in prokaryotes, binds domain II of the 23S rRNA as well as the 5S rRNA and is one of five ribosomal proteins that mediate the interactions 5S rRNA makes with the ribosome. The ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40693.1

    Gene LinkOut

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