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    IOC4 Ioc4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855061, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IOC4
    Official Full Name
    Ioc4p
    Primary source
    SGD:S000004647
    Locus tag
    YMR044W
    See related
    AllianceGenome:SGD:S000004647; FungiDB:YMR044W; VEuPathDB:YMR044W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ATP hydrolysis activity and DNA binding activity. Involved in chromatin remodeling and sister chromatid cohesion. Part of Isw1b complex. Orthologous to several human genes including HDGFL1 (HDGF like 1); HDGFL2 (HDGF like 2); and HDGFL3 (HDGF like 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IOC4 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (355384..356811)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Arg80p Neighboring gene transcription factor MCM1 Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene tRNA-His

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone H3 lysine 36 methylation targets the Isw1b remodeling complex to chromatin. Maltby VE, et al. Mol Cell Biol, 2012 Sep. PMID 22751925, Free PMC Article
    2. Isw1 acts independently of the Isw1a and Isw1b complexes in regulating transcriptional silencing at the ribosomal DNA locus in Saccharomyces cerevisiae. Mueller JE, et al. J Mol Biol, 2007 Aug 3. PMID 17561109, Free PMC Article
    3. Dependency of ISW1a chromatin remodeling on extranucleosomal DNA. Gangaraju VK, et al. Mol Cell Biol, 2007 Apr. PMID 17283061, Free PMC Article
    4. Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes. Stockdale C, et al. J Biol Chem, 2006 Jun 16. PMID 16606615, Free PMC Article
    5. Yeast Isw1p forms two separable complexes in vivo. Vary JC Jr, et al. Mol Cell Biol, 2003 Jan. PMID 12482963, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Isw1b complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ioc4p
    NP_013758.1
    • Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      355384..356811
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182541.1 → NP_013758.1  TPA: Ioc4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013758.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZL9, Q04213
      UniProtKB/TrEMBL
      C7GL75, N1NYN4
      Conserved Domains (1) summary
      cd05840
      Location:6 → 161
      SPBC215_ISWI_like; The PWWP domain is a component of the S. pombe hypothetical protein SPBC215, as well as ISWI complex protein 4. The ISWI (imitation switch) proteins are ATPases responsible for chromatin remodeling in eukaryotes, and SPBC215 is proposed to also bind ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04213.1

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